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相关概念视频

Preclinical Development: Overview01:28

Preclinical Development: Overview

5.7K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Drug Discovery: Overview01:26

Drug Discovery: Overview

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
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In Vitro Drug Release Testing: Overview, Development and Validation01:10

In Vitro Drug Release Testing: Overview, Development and Validation

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In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
279
Drug Regulation01:25

Drug Regulation

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Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
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相关实验视频

Updated: Jan 7, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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药物开发 药物开发

Wahyu Dewi Tamayanti1,2, Agnes Dwi Ariyanti1, Haw Yuan Cheng1

  • 1Institute of Brain Science, Schools of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan, Taipei City, Taiwan.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
概括
此摘要是机器生成的。

作为CSF1R抑制剂的ENrupatinib在阿尔茨海默病小鼠模型中降低了神经炎症并保存了神经元. 这种阿尔茨海默氏症治疗改善了认知功能,显示了疾病修饰的潜力.

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In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
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Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
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In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
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Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
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科学领域:

  • 神经科学是一个神经科学.
  • 免疫学 免疫学 免疫学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 阿尔茨海默病 (AD) 的特征是由微质激活和炎症性细胞因子驱动的神经炎症.
  • 调节微质活动是阿尔茨海默病的有希望的治疗策略.
  • 脑透的CSF1R抑制剂恩鲁帕替尼 (enrupatinib) 在AD小鼠模型中被研究其疾病修饰潜力.

研究的目的:

  • 在阿尔茨海默氏病模型中评估恩鲁帕提尼布对神经元完整性和微质反应的影响.
  • 评估恩鲁帕提尼布对神经炎症,粉样蛋白病理和认知功能的影响.

主要方法:

  • 利用阿尔茨海默病的5xFAD和J20小鼠模型.
  • 通过新型物体识别 (NOR) 和Y-迷宫测试给药恩鲁帕提尼布 (300 mg/kg),并通过新型物体识别 (NOR) 和Y-迷宫测试评估认知功能.
  • 分析了微质,粉样斑块和神经元的健康状况,使用显微镜,免疫光学,qPCR,西部涂抹和RNA测序.

主要成果:

  • 恩鲁帕提尼布治疗降低了神经炎症标志物和与疾病相关的微质细胞 (DAM) 基因表达.
  • 观察到较低的粉样质斑沉积趋势和显著减少的神经元分裂.
  • 恩鲁帕提尼布治疗在行为测试中提高了认知表现,并降低了炎症通路的调节.

结论:

  • 恩鲁帕提尼布在缓解阿尔茨海默氏症病理方面显示出显著的潜力.
  • 该药物有效地减少神经炎症,并保持神经元的完整性.
  • 恩鲁帕替尼布是阿尔茨海默病治疗的有希望的治疗候选者.