Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Landscape of copy number variants in Spanish people with dementia.

NPJ genomic medicine·2026
Same author

Epigallocatechin-3-gallate attenuates colistin-induced neuro and nephrotoxicity by preserving mitochondrial function and reducing oxidative stress.

Biochemical pharmacology·2026
Same author

Licochalcone a enhances cognitive resilience in APP/PS1 Mice by modulating glucose metabolism, Aβ burden, and neuroinflammation.

GeroScience·2026
Same author

Listening for Alzheimer's clues: machine learning analysis of multidomain speech features for cognitive impairment screening.

Frontiers in aging neuroscience·2026
Same author

Non-linear associations between sleep duration and plasma p-tau181 in the Framingham Heart Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer's disease.

Nature aging·2026
Same journal

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

生物标志物 生物标志物

Bart Smets1, Asif Emon2, Yanfei Zhang3

  • 1Janssen Pharmaceutica NV, a Johnson & Johnson company, Beerse, Belgium.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
概括
此摘要是机器生成的。

阿尔茨海默病 (AD) 除了粉样蛋白和病理之外,还具有不同的分子亚型. 使用CSF蛋白质组学识别这些亚型可以改善AD患者的诊断和治疗策略.

更多相关视频

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

相关实验视频

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

科学领域:

  • 神经科学是一个神经科学.
  • 生物标志物 生物标志物
  • 蛋白质组学是指蛋白质组学.

背景情况:

  • 根据A/T/N框架,阿尔茨海默病 (AD) 根据粉样斑块 (A) 和团 (T) 进行分类,通过液体和成像生物标志物进行早期诊断.
  • 然而,A/T/N框架并不涵盖所有AD的发病途径,因为共同病理显著影响疾病的进展和治疗反应.

研究的目的:

  • 通过使用脑脊液 (CSF) 蛋白质学来识别不同的患者亚组,研究阿尔茨海默病 (AD) 中的分子异质性.
  • 为了比较已识别的AD亚型的临床,遗传和分子特征,并评估它们与疾病阶段的关系.
  • 使用血蛋白学开发CSF亚型的预测模型.

主要方法:

  • 在西班牙ACE队列中分析了来自705个CSF粉样蛋白水平异常的人的CSF蛋白质组数据.
  • 应用共识聚类来识别AD患者的分子亚型.
  • XGBoost分类器受过训练,可以从血蛋白质组学数据中预测CSF亚型.

主要成果:

  • 确定两个强大的CSF亚型: (1) 神经元可塑性高,CSFp-tau181和t-tau升高,以及 (2) 血脑屏障功能障碍,涉及补充,炎症和凝血通路.
  • 在神经元损伤标志物或疾病进展率上没有观察到显著差异,这表明分子异质性而不是疾病阶段差异.
  • 基因分析揭示了亚型的不同潜在病因,表明需要量身定制的治疗模式. 血蛋白质学准确地预测了CSF亚型 (AUC> 0.8).

结论:

  • 这项研究证实了AD的独特分子亚型,该亚型使患者的分层超出了A/T/N分类.
  • 在额外的队列和临床试验中进一步验证对于提高AD诊断,预后和治疗的精度至关重要.
  • 针对这些亚型的基于血液的生物标志物的开发将在阿尔茨海默病研究中显著推进个性化医学方法.