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相关概念视频

Preclinical Development: Overview01:28

Preclinical Development: Overview

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Clinical Trials: Overview01:11

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Drug Discovery: Overview01:26

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Drug Administration and Therapy Phases: Overview01:26

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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
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In Vitro Drug Release Testing: Overview, Development and Validation01:10

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In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
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Drug Regulation01:25

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Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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药物开发 药物开发

Alexander C Conley1, S Shizuko Morimoto2, Jennifer N Vega3

  • 1Center for Cognitive Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
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PubMed
概括
此摘要是机器生成的。

神经,一种新的认知训练计划,是对轻度认知障碍 (MCI) 的可行和耐受性良好的干预措施. 这种基于神经可塑性的计算机认知补救 (nCCR) 显示,MCI的成年人认知功能和日常功能得到改善.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是指老年学的学科.
  • 认知心理学 认知心理学

背景情况:

  • 认知训练为轻度认知障碍 (MCI) 提供了一种治疗途径,有可能改善认知能力,并且比药物治疗更少的副作用.
  • 基于神经可塑性的计算机认知补救 (nCCR) 是一种新兴的策略,通过准皮质网络来提高认知表现.
  • 这项研究调查了特定的nCCR干预措施Neuroflex在被诊断为MCI的成年人中的可行性和耐受性.

研究的目的:

  • 评估MCI成年人的Neuroflex干预措施的可行性和耐受性.
  • 在MCI人群中探索nCCR后认知和功能改善的初步证据.
  • 建立未来随机对照试验的基础,调查nCCR疗效.

主要方法:

  • 这是一项涉及19名患有MCI的参与者 (11名女性,平均年龄为73.3岁) 的开放性研究.
  • 参与者在六周内完成了45小时的Neuroflex培训,通过视频会议进行远程辅导.
  • 在干预期间和之后,通过问卷和任务评估认知表现和功能参与.

主要成果:

  • 神经体表现出良好的耐受性,完成率高达84.2% (19名参与者中有16名).
  • 在自我和告知者报告的功能方面观察到显著的改善,包括感知到的个人优势和减少的痴呆症症状.
  • 参与者表现出提高工作记忆性能 (2-back任务),并在干预后进行go/nogo任务时提高准确性.

结论:

  • 神经是一种可行的,耐受性良好的干预措施,适用于患有MCI的成年人.
  • 观察到的认知和功能上的好处表明Neuroflex作为MCI的辅助疗法的潜力.
  • 这些初步发现支持在随机对照试验环境中进一步调查Neuroflex.