生物标志物 生物标志物
Srishti Shrestha1, Xiaoqian Zhu1, B Gwen Windham1
1University of Mississippi Medical Center, The MIND Center, Jackson, MS, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
针对质和神经元功能障碍以及神经炎症的血液生物标志物与成年人更快的认知衰退和痴呆风险增加有关. 这些标记可能有助于识别患阿尔茨海默病和相关痴呆症 (ADRD) 风险较高的个体.
科学领域:
- 神经学 神经学
- 生物标志物研究 生物标志物研究
- 老年学是一门学科.
背景情况:
- 对阿尔茨海默病和相关痴呆症 (ADRDs) 生物标志物的研究主要集中在粉样β和病理上.
- 在社区群体中研究质和神经元功能障碍和神经炎症的生物标志物的研究是有限的.
- 这项研究检查了与认知衰退和痴呆风险相关的新型血液生物标志物.
研究的目的:
- 为了研究血液生物标志物反映质/神经元功能障碍和神经炎症与25年内认知能力下降的关联.
- 评估这些生物标志物与发展痴呆症的风险之间的关系.
- 探索这些生物标志物在早期ADRD诊断和风险分层中的实用性.
主要方法:
- 来自ARIC研究的1864名参与者接受了血液生物标志物 (sCD14,YKL-40,GFAP,NfL,总-Tau,UCH-L1) 的测量.
- 认知功能在25年内被评估了多达6次,并且通过各种确定方法确定了痴呆病例.
- 使用共享参数模型分析与每个生物标志物相关的认知衰退和痴呆风险,并对共变量进行调整.
主要成果:
- 大多数生物标志物的较高水平 (除UCH-L1外的所有生物标志物) 与更快的认知衰退和痴呆风险增加有关.
- 例如,YKL-40的一个SD增加与更的认知衰退和59%更高的痴呆风险有关.
- sCD14还与加速的认知衰退和38%的痴呆风险增加有关.
结论:
- 血中的生物标志物表明微质激活,星细胞反应和神经元退化与认知能力下降和痴呆风险有关.
- 这些发现表明,这些生物标志物在ADRD风险分层和干预策略中具有潜在的实用性.
- 进一步的研究将探讨基于种族和APOE-ε4地位的这些协会的差异.
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