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相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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生物标志物 生物标志物

Shuhua Ren1, Yihui Guan2, Fang Xie3

  • 1Huashan Hospital, Shanghai, China.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
概括

主观认知衰退 (SCD) 患者表现出明显的粉胺β (Aβ) 沉积模式和轻微的神经退行. 大脑Aβ水平与执行功能相关,而海马体积与整体认知和语言能力有关,这表明早期阿尔茨海默病的生物标志物.

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科学领域:

  • 神经科学是一个神经科学.
  • 放射学 放射学是一门学科.
  • 老年学是指老年学的学科.

背景情况:

  • 阿尔茨海默病 (AD) 涉及Aβ沉积,改变葡萄糖代谢和灰色物质体积 (GMV) 损失,特别是在海马和副海马圈.
  • 主观认知衰退 (SCD) 代表了潜在的AD之前的认知障碍的早期阶段.
  • 在SCD中调查这些病理特征对于早期诊断和干预至关重要.

研究的目的:

  • 为了检查SCD患者的大脑Aβ沉积,葡萄糖代谢,GMV和神经退行.
  • 探索这些神经成像标记物与SCD患者认知功能之间的关系.

主要方法:

  • 144名参与者 (95名SCD,49名对照) 接受了神经心理测试,18F-Florbetapir PET/CT,18F-FDG PET/CT和MRI.
  • 在Voxel-wise分析中,在SCD和对照组之间发现了Aβ沉积,葡萄糖代谢和GMV的差异.
  • 相关性分析评估了神经成像发现与认知表现之间的关联.

主要成果:

  • 与对照人群相比,SCD患者在前骨,后 cingulate 骨和左前双叶中表现出较高的Aβ沉积.
  • 在左下部区域观察到轻微的缩,右侧副海马回形中葡萄糖代谢减少.
  • Aβ沉积与执行功能正相关,海马/准海马体积与整体认知,执行和语言功能相关.

结论:

  • SCD患者表现出特定的Aβ沉积模式和轻微的神经退行,主要在左半球.
  • 神经成像标记物,如Aβ沉积和海马体积,与认知功能有显著的相关性.
  • 这些发现凸显了多式神经成像技术在SCD中识别早期AD生物标志物的潜力.