临床表现 临床表现
Hanlin Cai1, Keru Huang1, Zilong Hao1
1West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
数字评估显著改善了在异常性正常压力脑症 (iNPH) 患者中分离成功的预测. 这些先进的测试比评估iNPH治疗反应的传统方法提供了更好的结果.
科学领域:
- 神经学 神经学
- 生物医学工程 生物医学工程
- 老年病的医生 老年病的医生
背景情况:
- 异常性正常压力脑症 (iNPH) 是一种可治疗的神经疾病.
- 脑脊液 (CSF) 转移手术可以改善iNPH症状.
- 预测iNPH患者的分离结果对于治疗成功至关重要.
研究的目的:
- 评估数字神经心理和步态评估对iNPH患者的分离结果的预测价值.
- 为了比较数字评估与传统方法在预测分离反应中的有效性.
- 确定在外部腰部排水 (ELD) 期间评估iNPH患者的客观标记.
主要方法:
- 对70名可能的INPH患者进行前性队列研究.
- 使用传统和数字认知/步态测试进行基线和72小时ELD后评估.
- 在3个月后,随随访分离手术,用iNPH分级表来衡量结果.
- 多变量物流回归和ROC分析以确定预测值.
主要成果:
- 数字神经心理测试和步态分析显示,在ELD后显著改善.
- 数字评估中的更高的改进率与更高的转移后改进概率相关 (OR=1.06,p=0.021).
- 与传统测试 (AUC=0.67) 相比,数字评估实现了更高的预测效率 (AUC=0.91).
结论:
- 数字神经心理和步态评估是评估iNPH患者在ELD期间的客观工具.
- 这些数字方法提高了iNPH中分流结果的预测.
- 数字评估为iNPH管理提供了比传统测试更准确,更可靠的替代方案.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437


