AYA-NAV,一个基于患者的,针对癌症青少年和年轻成年人的需求导航干预:试点研究
Rhea K Khurana1, Rohit Raghunathan2, Sabrina Alvarado1
1School of Nursing, Columbia University Irving Medical Center, New York, NY, USA.
Cancer control : journal of the Moffitt Cancer Center
|December 26, 2025
概括
一项试点研究发现,AYA-NAV干预是解决癌症青少年和年轻人的财务毒性和与健康相关的社会需求 (HRSN) 的可行方法. 这种导航支持改善了参与者的金融毒性得分.
科学领域:
- 在瘤学瘤学.
- 医疗保健服务研究 医疗服务研究
- 健康的社会决定因素
背景情况:
- 患有癌症的青少年和年轻人 (AYA) 面临重大挑战,包括财务毒性和未满足的与健康有关的社会需求 (HRSN).
- 这些障碍对健康结果和参与幸存者护理有负面影响.
- 需要导航,一个选,转介和后续的过程,在减轻经济困难方面显示出希望.
研究的目的:
- 评估AYA-NAV的可行性,AYA-NAV是一个针对癌症患者的集中需求导航干预措施.
- 评估AYA-NAV在解决金融毒性和HRSN方面的可接受性和有效性.
主要方法:
- 一项前性试点研究选了AYA (15-39岁) 的财务毒性 (COST分数≤22) 和未满足的HRSN.
- 符合条件的参与者获得了AYA-NAV干预,包括案例管理和数字导航支持.
- 每月的检查和六个月的后续调查评估了需求和COST分数的变化.
主要成果:
- 30个AYA同意,其中87%的查结果为金融毒性或HRSN阳性.
- 23个AYA接受了AYA-NAV干预,在6个月内保持65%.
- 参与者报告说AYA-NAV是可以接受和有效的,在完成随访的人群中,COST分数显著增加 (P=0.024).
结论:
- 对于患有癌症的AYA,AYA-NAV干预是可行的.
- 这些发现支持AYA-NAV的改进和更大规模的随机试验以确认有效性.
- 通过导航解决金融毒性和HRSN问题对于改善AYA的癌症护理至关重要.
相关概念视频
Treatment Resistant Cancers
3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K
Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
Cancer Survival Analysis
626
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
626
Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
Mouse Models of Cancer Study
6.3K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.3K
Bioavailability Study Design: Healthy Subjects Versus Patients
130
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
130


