生物标志物 生物标志物
Mathias Holsey Gramkow1, Helena Sophia Gleerup1, Anja Hviid Simonsen2
1Danish Dementia Research Centre, Dept. of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
来自可穿戴设备的数字生物标志物显示出早期阿尔茨海默病 (AD) 检测的前景. 然而,在它们的诊断和预后应用中存在研究缺口,阻碍了临床使用.
科学领域:
- 神经学 神经学
- 生物医学工程 生物医学工程
- 数字健康数字健康
背景情况:
- 阿尔茨海默病 (AD) 管理正在随着新疗法的发展而发展,增加了早期检测和监测的需求.
- 来自数字健康技术 (DHT) 的数字生物标志物为量化疾病进展提供了一个有希望的途径.
- 目前缺乏对早期AD的数字生物标志物研究的全面了解.
研究的目的:
- 使用可穿戴或便携设备对早期阿尔茨海默病 (AD) 数字生物标志物的范围审查.
- 绘制现有研究格局的地图,识别方法,应用和知识差距.
主要方法:
- 搜索了三个主要的数据库 (MEDLINE,科学网络,EMBASE) 进行原始研究研究.
- 包括的研究集中在患有轻度认知障碍 (MCI) 或因AD而导致轻度痴呆症的个体的非认知数字生物标志物上.
- 查和数据提取由两名独立审查员使用Covidence软件进行.
主要成果:
- 包括109项研究,分析了来自6800多名早期阿尔茨海默病 (MCI或轻度痴呆症) 患者的数据.
- 大多数研究集中在休息/活动,言语和图形运动功能的数字生物标志物上.
- 很少有研究报告数字生物标志物的诊断 (16%) 或预后 (3%) 实用性,只有一个关于治疗监测的研究.
结论:
- 对早期AD的数字生物标志物进行越来越多的研究,这是新兴疗法的关键人群.
- 关于这些生物标志物的诊断和预后价值,存在重大知识差距.
- 需要进一步的研究来弥合数字生物标志物开发和AD早期临床实施之间的差距.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516