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相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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生物标志物 生物标志物

Hanzhang Lu1

  • 1Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
概括

脑液交换对功能至关重要,其中断与阿尔茨海默病和相关痴呆症 (ADRD) 有关. 新的MRI技术现在可以评估血脑屏障 (BBB) 透性和淋巴功能,提供对ADRD病原学的见解.

科学领域:

  • 神经成像是一种神经成像.
  • 生物医学工程 生物医学工程
  • 神经学 神经学

背景情况:

  • 神经流体交换对大脑健康至关重要;干扰与阿尔茨海默病和相关痴呆症 (ADRD) 有关.
  • 与粉样蛋白相关的成像异常 (ARIA) 是与ADRD相关的临床表现.
  • 评估神经流体动力学是理解神经退行性疾病机制的关键.

研究的目的:

  • 讨论非对比MRI的进展,以评估多个大脑接口中的神经流体交换.
  • 在ADRD和ARIA的背景下探索这些MRI技术的应用.
  • 突出MRI在评估血脑屏障 (BBB) 透性,动脉完整性和淋巴功能方面的潜力.

主要方法:

  • 使用非对比的MRI来图像血脑屏障 (BBB) 对水的透性.
  • 使用MRI来评估动脉血管完整性作为微型血液和ARIA风险的标记.
  • 使用MRI测量间歇液体 (ISF) 和周血管空间 (PVS) 之间的水交换,以评估淋巴功能.

主要成果:

  • 在轻度认知障碍 (MCI) 患者中观察到BBB对水的透性升高,与CSF生物标志物和认知得分相关.
  • 动物模型证实了阿尔茨海默病 (AD) 模型中的BBB透率增加,在治疗后可逆.

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  • 长回声时间的动脉旋转标记 (ASL) MRI显示了识别ARIA风险和评估淋巴功能的潜力.

    • 结论:

    • 先进的MRI技术可以评估关键大脑接口之间的神经流体交换.
    • 这些MRI方法为神经流体动力学在神经退行性疾病发病过程中的作用提供了宝贵的见解.
    • 非对比的MRI对早期检测和监测ADRD和ARIA等疾病充满希望.