生物标志物 生物标志物
Sarah N Forrester1, Jordan E Tanley2, Michael P Bancks2
1University of Massachusetts Chan School of Medicine, Worcester, MA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
种族歧视与认知衰退的脑成像标志物有关,特别是在少数群体中. 这些关联因种族而异,凸显了歧视对大脑健康的影响.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 社会学 社会学 社会学
背景情况:
- 歧视是健康的社会决定因素.
- 种族歧视可能导致阿尔茨海默病 (AD) 和相关痴呆症的健康差异.
- 歧视,血管和AD生物标志物之间的关联可能解释少数群体中痴呆风险过高.
研究的目的:
- 调查种族歧视与脑成像生物标志物之间的关系.
- 检查这些关联是否在各民族种族群体之间存在差异.
主要方法:
- 利用了MESA前性队列研究 (n=6,814) 的数据.
- 在基线评估了种族歧视经历和负担.
- 在后续检查期间收集的大脑MRI (n=1,372) 和粉样蛋白PET (n=422) 数据.
- 分析了歧视与大脑小血管疾病 (白质高强度,大脑微型血流,大脑周血管空间) 和粉样蛋白PET阳性之间的关联,按种族群体分层.
主要成果:
- 黑人和西班牙裔参与者报告了更高的种族歧视率.
- 种族歧视与黑人和西班牙裔参与者的周血管空间扩大,以及黑人和西班牙裔参与者的白质超强度有关.
- 终身歧视与西班牙裔参与者的大脑微型出血率更高有关.
- 较高的歧视负担与黑人参与者的大脑粉样蛋白负担增加有关.
结论:
- 终身种族歧视及其负担与与认知功能相关的大脑成像生物标志物有关.
- 这些关联在特定的民族种族群体中更为明显,这凸显了歧视对大脑健康的影响.
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