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Updated: Jan 7, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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药物开发 药物开发

Rijwan Uddin Ahammad1, Brian Spencer1, Robert A Rissman1

  • 1Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
概括

一种针对Lewy体痴呆症 (DLB) 的新型针对α-synuclein (α-syn) 的治疗方法显示出有前途的结果. ApoB11的系统输送:ASOα-syn降低了α-syn聚合物,改善了认知和运动功能,并在小鼠中增强了神经元存活率.

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