生物标志物 生物标志物
Jessica Hira1, Reza Zomorrodi2, Daniel M Blumberger3
1Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
在阿尔茨海默氏症痴呆症 (AD) 中,上纵 (SLF) 中白质损伤增加与运动皮层 (MC) 刺激性相关,这表明存在补偿机制. 这与皮层厚度的发现形成鲜明对比.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 不正常的皮层刺激性是阿尔茨海默氏症痴呆症 (AD) 中神经退行症的标志.
- 在阿尔茨海默氏症中,皮层刺激性和大脑结构变化之间的关系尚不清楚.
- 这项研究调查了运动皮层 (MC) 刺激性,皮层厚度和白质完整性之间的联系.
研究的目的:
- 评估运动皮层 (MC) 刺激性,皮层厚度和阿尔茨海默氏症痴呆症 (AD) 白质完整性之间的关系.
- 测试MC兴奋度与皮层厚度或白质管道完整性在上纵 (SLF) 之间的反向关联的假设.
主要方法:
- 参与者包括患有AD和认知正常 (CN) 的老年人.
- 通过单脉冲的跨脑磁刺激 (TMS) 和EEG测量了MC刺激性.
- T1加权的MRI和扩散加权的MRI量化了皮质厚度和SLF白质完整性 (平均扩散率[MD]和小数异构性[FA]).
主要成果:
- 与CN个体相比,患有AD的个体表现出降低了MC厚度,增加了SLFMD,以及降低了SLFFA.
- 在AD和CN组之间,MC刺激性没有显著差异.
- 在AD组中,增加的SLFMD与MC刺激性正相关;没有发现与皮质厚度或SLFFA有显著的相关性.
结论:
- 上部纵向 (SLF) 在运动控制和大脑连接方面发挥着至关重要的作用.
- 在AD中,SLF平均扩散度 (MD) 和MC兴奋度之间的正相关性可能表明神经退行症的补偿反应.
- 这些发现突显了阿尔茨海默氏症痴呆症中白质完整性和皮质刺激性之间的复杂相互作用.
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