Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Preclinical Development: Overview01:28

Preclinical Development: Overview

5.7K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
5.7K
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.5K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.5K
Drug Discovery: Overview01:26

Drug Discovery: Overview

10.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.9K
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

1.1K
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
1.1K
In Vitro Drug Release Testing: Overview, Development and Validation01:10

In Vitro Drug Release Testing: Overview, Development and Validation

279
In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
279
Drug Regulation01:25

Drug Regulation

2.7K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
2.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Mediating Role of Plasma Biomarkers Associated with Metabolic Syndrome in Cognitive Decline Among Older Adults.

Diabetes, metabolic syndrome and obesity : targets and therapy·2026
Same author

Isolation, Structural Characterization, and Potent Leishmanicidal, Anti-Cancer, and Anti-Microbial Activities of a New Diosgenin Glycoside from Malvastrum coromandelianum.

Applied biochemistry and biotechnology·2026
Same author

Toxicity assessment of <i>Mitragyna speciosa</i> leaf extracts using zebrafish (<i>Danio rerio</i>) embryos and analysis of their Q-TOF LCMS chemical profiles.

Natural product research·2026
Same author

TM4SF1 regulates esophageal squamous cell carcinoma KYSE150 cell phenotypes via miRNA-regulated pathways.

Cytotechnology·2026
Same author

Antimicrobial and antioxidant activities of <i>Tetracera macrophylla</i> Hook.f. & Thomson leaf extracts: insights from Q-ToF-LCMS, pharmacokinetics and molecular docking approach.

Natural product research·2026
Same author

Low-dose of yeast beta-glucan on respiratory symptoms and psychological well-being in moderately stressed adults.

iScience·2026

相关实验视频

Updated: Jan 7, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

10.1K

药物开发 药物开发

Aiman Hamli1, Kalavathy Ramasamy2,3, Snezana Agatonovic-Kustrin4,5

  • 1Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Selangor, Malaysia.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
概括
此摘要是机器生成的。

海藻Caulerpa lentillifera提取物通过减少氧化应激和炎症,显示出对阿尔茨海默病的神经保护潜力. 对这些天然化合物的进一步研究可能会导致神经退行性疾病的新疗法.

更多相关视频

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
08:04

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

3.3K
Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
05:45

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

451

相关实验视频

Last Updated: Jan 7, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

10.1K
In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
08:04

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

3.3K
Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
05:45

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

451

科学领域:

  • 海洋生物学 海洋生物学
  • 神经科学是一个神经科学.
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 目前的阿尔茨海默氏病 (AD) 治疗提供症状缓解,但不能阻止疾病的进展.
  • 神经炎症在阿尔茨海默氏症的发病过程中发挥着关键作用,需要新的神经保护策略.
  • 海洋藻类Caulerpa lentillifera具有抗氧化和抗炎性质,表明其可能用于AD干预.

研究的目的:

  • 在实验室中研究Caulerpa lentillifera提取物对脂聚糖 (LPS) 诱导的神经炎症的神经保护作用.
  • 评估不同C. lentillifera提取物的抗氧化和抗炎活性.
  • 为了确定负责观察到的神经保护作用的植物化学成分.

主要方法:

  • 使用甲醇提取C. lentillifera,并将其分成六,和乙烯酸部分 (CLME,CLHE,CLCE,CLEAE).
  • 使用HPTLC评估抗氧化活性 (DPPH清除) 和COX-1抑制.
  • 在LPS挑战的巨细胞 (RAW 264.7) 和神经母细胞瘤 (SK-N-SH) 细胞中评估提取物,测量ROS,NO和caspase-3活性.
  • 使用NMR光谱学进行植物化学分析.

主要成果:

  • CLCE显示出最高的DPPH清除活性,而CLEAE显示出最强的COX-1抑制.
  • 在LPS挑战的RAW 264.7细胞中,CLCE和CLHE显著降低了ROS,NO和caspase-3活性.
  • 此外,CLCE和CLHE还显著降低了LPS挑战的SK-N-SH细胞中的ROS和酶-3活性.
  • 植物化学分析表明,CLCE具有最高的含量,在所有提取物中确定了各种化合物.

结论:

  • C. lentillifera 提取物,特别是 CLCE 和 CLHE,具有显著的神经保护潜力.
  • 这些提取物通过减少氧化应激,炎症和亡来减轻神经炎症.
  • C. lentillifera代表了开发用于阿尔茨海默病的新型治疗剂的有希望的来源.