生物标志物 生物标志物
Srijan Konwar1, Riccardo Manca2,3, Matteo De Marco4
1Brunel University London, Uxbridge, United Kingdom.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
阿尔茨海默氏症 (AD) 的血管并发症导致大脑发生广泛的变化. 具有血管问题的认知能力正常的个体表现出增强的大脑连接,与认知能力下降的人不同.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 阿尔茨海默氏症 (AD) 经常与血管病理共同发生,影响疾病的进展和临床表现.
- 了解阿尔茨海默病中血管并发症的神经成像模式对于表征疾病异质性至关重要.
研究的目的:
- 系统地审查阿尔茨海默氏病和同时存在的血管病理的个体的结构和功能神经成像发现.
主要方法:
- 按照PRISMA指南进行系统的文献审查.
- 在PubMed,Scopus和Web of Science中搜索了关于AD连续性的研究.
- 包括67篇关于结构成像和49篇关于功能成像分析的论文.
主要成果:
- 血管并发症与广泛的皮层稀释,体积损失和AD易受地区白质完整性降低有关.
- 具有血管病理的认知能力正常的个体在感觉运动和视觉网络中表现出更高的功能连接性,皮层厚度和皮层下体积更大.
- 受损的个体表现出广泛的皮质稀薄,体积损失和功能连接能力较弱.
结论:
- 血管负担对大脑结构和功能产生广泛的影响,影响AD易受感染的区域,感觉运动/视觉网络和深层皮质下区域.
- 基于认知状态出现了不同的神经成像模式:受损个体表现出广泛的缩和减少的连接性,而不受损的个体显示出区域厚度,体积和连接性的补偿性增加.
相关概念视频
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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516