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临床表现 临床表现

Nadeshka J Ramirez-Perez1, Lusiana Martinez2, Randy Medrano2

  • 195 Grant Avenue, Medford, MA, USA.

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拉丁美洲西班牙语临床前阿尔茨海默氏症认知组合 (LAS-PACC5) 准确评估西班牙语拉丁人的认知能力. 这种工具有效地识别认知障碍,有助于早期发现阿尔茨海默病风险.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 心理测量 心理测量 心理测量

背景情况:

  • 西班牙语的认知评估对于评估拉丁裔人口中阿尔茨海默病 (AD) 风险至关重要.
  • 拉丁美洲西班牙临床前阿尔茨海默氏症认知复合物 (LAS-PACC5) 是为了检测早期认知变化而开发的.
  • 使用现有的认知测量来检查LAS-PACC5的关联和诊断能力.

研究的目的:

  • 在拉丁裔人口中验证拉丁美洲西班牙临床前阿尔茨海默氏症认知复合物 (LAS-PACC5).
  • 评估LAS-PACC5与现有认知措施的相关性.
  • 评估LAS-PACC5区分认知无损和认知受损个体的能力.

主要方法:

  • 包括来自波士顿拉丁裔老龄化研究 (BLAST) 的191名西班牙语参与者.
  • 适应的LAS-PACC5,包括MMSE,FCSRT和Category Fluency,与其他认知测试一起进行.
  • 统计分析包括曼-惠特尼U测试和部分斯皮尔曼相关性,根据年龄和教育进行调整.

主要成果:

  • 拉斯-PACC5证明了与记忆和语言测量 (神经系统单词列表,语义流,MINT) 的正相关性.
  • 拉斯-PACC5显著区分无障碍和有障碍的参与者.
  • 在区分认知组之间观察到一个很大的效果大小.

结论:

  • 拉斯-PACC5表现出与记忆和语言评估的融合有效性.
  • LAS-PACC5可靠地检测西班牙语老拉丁人的认知障碍.
  • 未来的研究应该专注于纵向研究和AD相关的生物标志物.