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临床表现 临床表现

Meaghan Am McKenna1, Charlotte B Curnin1, John Torous1

  • 1Beth Israel Deaconess Medical Center, Boston, MA, USA.

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概括
此摘要是机器生成的。

一个新的在线认知测试,D-Cog,显示在家中阿尔茨海默病监测的希望. 这种工具可以检测认知变化,有助于早期诊断诸如妄想症或ARIA等疾病.

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科学领域:

  • 神经学 神经学
  • 老年学是一门学科.
  • 数字健康数字健康

背景情况:

  • 早期阿尔茨海默病 (AD) 患者经历认知波动.
  • 变化可以标志着严重的疾病,如幻觉或ARIA从粉样蛋白降低疗法.
  • 目前的工具缺乏常见的家庭认知评估能力.

研究的目的:

  • 研究在家使用的新型在线认知评估 (D-Cog) 的实用性,方便性和可行性.
  • 评估D-Cog在AD患者中检测认知变化的潜力.
  • 评估D-Cog作为一种用于早期检测妄或ARIA的工具.

主要方法:

  • 开发了D-Cog,这是一个简短的 (<2分钟) 在线认知测试,旨在作为"认知生命体征".
  • 收集了82名患有MCI或AD的试点数据.
  • 招募了15名参与者进行6个月的每日家庭D-Cog评估,并进行远程监测.

主要成果:

  • 54名参与者 (平均年龄76岁) 完成了这项研究,平均D-Cog得分为3.9.
  • D-Cog得分与迷你精神状态检查 (MMSE) 的得分高度相关 (r=0.56,p=1.3e-5).
  • 患者报告D-Cog在家中很容易完成.

结论:

  • 在临床实践和AD患者在家中远程使用时,D-Cog评估是可行的.
  • D-Cog得分与传统的神经心理测试有很好的相关性.
  • 对于频繁,方便的家庭监测和早期检测认知变化,D-Cog显示出有前途.