临床表现 临床表现
Peter J Morin1, Ying Wang2, Joel Reisman3
1Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
这项研究确定了日常生活工具活动 (IADL) 评分门,以分阶段阿尔茨海默病 (AD) 进展,并将其与蒙特利尔认知评估 (MoCA) 评分相关联,用于临床分阶段. 这些发现为使用IADL测量方法评估AD严重程度提供了一种新方法.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 传统上,阿尔茨海默氏症 (AD) 病期依赖于认知评估.
- 日常生活中的工具性活动 (IADL) 提供了疾病进展的功能性衡量标准.
- 对于全面的AD分期,需要认知 (MoCA) 和功能 (IADL) 评分之间的验证过的交叉步行.
研究的目的:
- 使用日常生活工具活动 (IADL) 评分来定义阿尔茨海默病 (AD) 的临床阶段.
- 建立蒙特利尔认知评估 (MoCA) 成绩和IADL绩效之间的交叉步行.
- 提供IADL得分值,对应于AD的不同阶段,从正常认知到严重痴呆.
主要方法:
- 从退伍军人事务医疗保健系统 (VAHS) 数据库 (2020-2024) 中回顾分析患者数据.
- 包括被诊断患有轻度认知障碍 (MCI) 或阿尔茨海默氏症痴呆症 (AD) 的患者.
- 蒙特利尔认知评估 (MoCA) 和劳顿-布罗迪IADL分数的对分析使用线性,重复测量和分类回归模型.
主要成果:
- 总共分析了1327名患者 (平均年龄为80.1岁,97.4%为男性).
- 对于正常认知,MCI和轻度,中度和重度的AD,定义了特定的MoCA分数截止值.
- 对每个认知阶段确定了相应的IADL分数范围和平均值,分类回归显示了轻度至重度AD阶段的更好歧视.
结论:
- 成功确定了日常生活工具活动 (IADL) 评分门,以将阿尔茨海默病 (AD) 从正常阶段转变为严重阶段.
- 已建立的MoCA和IADL分数之间的交叉步行提供了AD临床阶段的AD临床阶段的功能指标.
- 分类回归分析证明了MoCA和IADL得分之间适应非线性关系的实用性,以提高分期准确性.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437


