临床表现 临床表现
Davi Melillo Cardoso1, Clarisse Vasconcelos Friedlaender2, Monica Sanches Yassuda3
1Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, Belo Horizonte, Minas Gerais, Brazil.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
概念转移测试 (CST) 与拉丁美洲执行职能 (EF) 的Trail Making Test (TMT) 有着中等的相关性. 不同的认知测试对于早期发现痴呆症至关重要,无论APOE-ε4状态如何.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 老年学是一门学科.
背景情况:
- 拉丁美洲面临着高痴呆风险.
- 早期发现认知能力下降,特别是执行功能 (EF),至关重要.
- 概念转移测试 (CST) 对EF评估具有前景,但需要适应拉丁美洲.
研究的目的:
- 检查CST与其他EF测试的相关性.
- 研究老年人中CST性能与APOE-ε4等位基因之间的关系.
- 评估CST在拉丁美洲认知评估中的实用性.
主要方法:
- 从LatAm-FINGERS研究的基线数据的横截面分析.
- 包括Trail Making Test (TMT),CST,Stroop Test,以及流利性的任务.
- 通过PCR-RFLP进行APOE基因定型;使用Jamovi软件分析相关性.
主要成果:
- 来自拉丁美洲11个国家的1,143名参与者.
- CST转移得分与TMT灵活性有中等相关性,与Stroop和流性任务有弱相关性.
- 在APOE-ε4载体和非载体之间没有发现CST或TMT性能的显著差异.
结论:
- CST和TMT测量执行功能的不同方面,CST可能提供更精细的认知灵活性测量.
- CST是拉丁美洲环境环境评估的一个有价值的工具,但并不取代TMT.
- 使用多种工具进行全面的认知评估对于早期发现痴呆症至关重要,无论APOE-ε4.4.等遗传风险因素如何.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437


