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药物开发 药物开发

Maxine R Nelson1, Marina Kovaliov1, Priyanka Singh1

  • 1Switch Therapeutics, South San Francisco, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
PubMed
概括

一种新的条件激活siRNA (CASi) 在阿尔茨海默病 (AD) 模型中有效降低大脑Apolipoprotein E (APOE) mRNA. 这种有针对性的方法节省了外围APOE和胆固醇,为APOE*ε4载体提供了有前途的治疗方法.

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