双极性障碍的季节性模式:与临床表现型的关联以及与治疗相关的结果
Siralp Bostan1,2, Lindsay M Melhuish Beaupre3, Mete Ercis1
1Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Acta psychiatrica Scandinavica
|December 26, 2025
概括
双相情感障碍 (BD) 的季节性模式与特定的临床特征和治疗结果有关. 秋冬抑郁症是一种特定的季节性模式,可能表明更复杂,更具挑战性的疾病过程需要量身定制的管理策略.
科学领域:
- 精神病学和行为科学
- 情绪障碍 研究 研究 情绪障碍
- 时间生物学 时间生物学
背景情况:
- 大约25%的双相情绪障碍 (BD) 患者经历了具有季节性模式的情绪发作.
- 了解这些季节性模式对于个性化治疗方法至关重要.
研究的目的:
- 研究BD中的特定季节性模式与临床表型之间的关联.
- 检查季节性模式与治疗相关结果之间的关系,包括药物暴露和对情绪稳定剂的反应.
主要方法:
- 利用了梅奥诊所双极性障碍生物库的数据,包括1702名有季节性数据的患者.
- 根据季节性分类的参与者分为四组:秋冬抑郁,春夏 (低) 躁狂,双相和等季节性.
- 采用回归模型来分析季节性模式与临床特征和治疗结果的关联.
主要成果:
- 44.6%的患者报告了季节性情绪发作,其特定模式与明显的临床特征有关.
- 秋冬抑郁症与抗抑郁药的使用增加,心理药物暴露和对情绪稳定剂的反应较差有关.
- 春夏 (低) 痴迷与快速骑自行车和抗抑郁药物使用有负面关联,而等季节性与精神病史有关.
结论:
- 在BD中,季节性与特定的临床特征和治疗结果有关,表明不同的疾病亚型.
- 秋冬抑郁模式可能表明BD的更复杂和耐治疗的过程.
- 强调需要对BD季节性进行细微分类,而不仅仅是简单的季节性/非季节性二分法,以改善疾病管理.
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