临床表现 临床表现
Rashmina Shrestha1, Cheryl Cheuk Yan Y Leung2, Latha Velayudhan2
1Oxleas NHS Foundation Trust, London, United Kingdom.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
与女性相比,轻度认知障碍 (MCI) 的男性表现出明显的神经精神症状 (NPS). 这项研究发现,在患有MCI的男性中,异常发音的患病率更高,易怒和失调症的严重程度更高.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 神经精神病症状 (NPS) 在轻度认知障碍 (MCI) 中越来越多地被识别为痴呆症的过渡阶段.
- 虽然阿尔茨海默氏症痴呆症的性别差异已被记录,但对MCI这些差异的研究是有限的.
- 这项研究调查了65岁以上MCI患者中NPS患病率和严重程度的性别差异.
研究的目的:
- 为了探索在轻度认知障碍中个体神经精神病症状的患病率中的性别差异.
- 评估轻度认知障碍中神经精神症状严重性的性别差异.
- 为了解性别在MCI表现中的作用做出贡献.
主要方法:
- 被诊断为轻度认知障碍 (ICD-10) 的参与者从英国的记忆服务中招募.
- 临床评估包括建立阿尔茨海默病登记册的联盟,迷你精神状态检查 (MMSE) 和神经精神病学库存-临床医生版本 (NPI-C).
- 分析了46名参与者的数据 (59%是女性,平均年龄为79.22岁),以确定特定性别的NPS模式.
主要成果:
- 患有MCI的男性表现出异常发音的明显更高的流行率 (p=0.03).
- 与女性相比,男性表现出明显更严重的易怒性 (p=0.10) 和失调性 (p=0.05).
- 参与者群体在迷你精神状态检查 (MMSE) 评分 (p=0.28) 中是可比的.
结论:
- 该研究强调了轻度认知障碍人群中神经精神病症状的患病率和严重性的显著性别差异.
- 进一步的研究至关重要,以阐明这些性别差异的潜在病理生理学.
- 了解这些差异可能有助于预测痴呆症的进展和制定有针对性的干预措施.
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