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科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 遗传学 是一个
  • 心理学 心理学 心理学

背景情况:

  • 漠不关心是早期阿尔茨海默病 (AD) 的常见症状,其特征是动机减少.
  • 老年人往往优先考虑亲社会行为,这种倾向可能会在AD早期持续存在.
  • 亲社会奖励在激励努力中的作用及其与高危老年人冷漠的关系仍然不清楚.

研究的目的:

  • 调查亲社会奖励是否比自我服务奖励更有效,以激励老年人患AD风险的努力.
  • 检查OPRL1基因中的遗传变异如何调节亲社会取向和冷漠之间的关系.

主要方法:

  • 52名患有阿尔茨海默症风险的老年人完成了一项计算机化任务,评估了对亲社会 (捐款) 和自我服务 (金钱) 奖励的努力.
  • 用各种函数分析了奖励-努力折扣曲线,以确定最合适的曲线.
  • 回归模型检查了亲社会取向和冷漠之间的关联,其中OPRL1单核酸多态 (SNP) rs6010718和rs6010719作为调节者.

主要成果:

  • 西格功能最好地描述了奖励-努力折扣曲线.
  • 与自我服务的激励相比,参与者对亲社会的激励付出了更多的努力,需要的奖励也更少.
  • OPRL1 rs6010718次要等位基因携带者表现出与亲社会努力相关的冷漠性减少,而rs6010719次要等位基因携带者表现出更高的冷漠性.

结论:

  • 面临阿尔茨海默病风险的老年人更愿意为亲社会奖励而付出努力,与自我服务相比,需要更小的激励.
  • 在OPRL1 SNPs中的遗传变异影响了亲社会取向和冷漠之间的相互作用.
  • 特定的OPRL1基因型可能与衰老期间亲社会努力的背景下,冷漠行为减少有关.