生物标志物 生物标志物
Jennifer G Cooper1, Nyra Ahmed1, Johnny Huang1
1University of British Columbia, Vancouver, BC, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
血生物标志物对阿尔茨海默病 (AD) 病理检测具有很高的特异性. 然而,低灵敏度表明这些标志物可能低估了COMPASS-ND研究中的AD患病率.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 神经学 神经学
背景情况:
- 神经退行和痴呆症综合评估 (COMPASS-ND) 研究是一项加拿大观察性研究,涉及患有痴呆症和认知投诉的参与者.
- 这项研究利用了等离子体生物标记物,包括粉样β (Aβ42/40),酸化-181 (p-tau-181),神经丝光 (NfL) 和状纤维酸性蛋白质 (GFAP).
- 这项研究旨在估计COMPASS-ND队列中阿尔茨海默病 (AD) 病理的流行率,并评估临床病理一致性.
研究的目的:
- 用血生物标志物估计COMPASS-ND队列中阿尔茨海默病 (AD) 病理的流行率.
- 评估临床诊断和潜在的AD病原体之间的一致性.
- 建立血生物标志物的切断值,这些生物标志物表明AD病理.
主要方法:
- 来自936名COMPASS-ND参与者的血样本使用Quanterix Simoa HD-X分析仪与神经学4-plex E和p-tau-181测定进行了分析.
- 一个由150名具有脑脊液 (CSF) 数据的参与者组成的子队列被用来通过接受器操作曲线 (AUROC) 下面的区域分析来确定血生物标志物的切断点.
- 已确定的切断线被应用于更大的队列,以估计不同诊断组中生物标志物阳性个体的百分比.
主要成果:
- 已经确定了血生物标记的切线值:Aβ42/40 <0.068 pg/mL,p-tau-181 >2.7 pg/mL,NfL >18.6 pg/mL,以及GFAP >134.9 pg/mL.
- 一个多生物标志物小组 (三分之二:Aβ42/40,p-tau-181,GFAP) 显示AD病理的敏感度为64%,特异性为83%.
- 据估计,阿尔茨海默病理的患病率在诊断组之间有所不同,从主观认知障碍的25%到阿尔茨海默病的83%和勒维体痴呆症的83%.
结论:
- 经测试的血生物标志物测试表明,在检测阿尔茨海默病 (AD) 病理方面具有很高的特异性.
- 这些生物标志物可以用来估计AD病理的流行率在更大的队列.
- 血生物标志物的低敏感性表明,在COMPASS-ND队列中潜在地低估了AD病理.
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