临床表现 临床表现
Andrew M Kiselica1, Leslie S Gaynor2,3, Kelly J Atkins4,5
1University of Georgia, Athens, GA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
这项研究提出了Delphi协议来定义早期阿尔茨海默病 (AD) 中的过渡性认知衰退 (TCD). 在TCD命名和测量方面达成共识对于在新的AD诊断标准的第二阶段识别个人至关重要.
科学领域:
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 新的阿尔茨海默病 (AD) 诊断标准包括一个六个阶段的分阶段方案 (1-6).
- 第二阶段的特点是生物标志物阳性和过渡性认知衰退 (TCD),没有损伤,缺乏明确的临床类比.
- 关于TCD定义的共识对于早期AD检测和临床试验招募至关重要.
研究的目的:
- 概述Delphi研究的协议,以建立关于AD中TCD的命名和测量的共识.
- 确保在新的AD诊断标准的第二阶段准确识别个人.
- 促进针对AD最早阶段的干预措施的发展.
主要方法:
- 将进行Delphi共识研究,由具有TCD,Delphi研究和混合方法研究专业知识的指导委员会指导.
- 一个由大约30名专家组成的小组将被选中参加这项研究.
- 在线调查将在三轮代中进行,并分析定性反以了解共识驱动因素.
主要成果:
- 研究协议包括Delphi面板选择,调查开发,重点关注TCD命名和测量,以及代数据收集.
- 共识将被定义为小组成员之间75%的协议.
- 将使用定性反来探索影响共识的因素.
结论:
- 德尔菲研究将产生基于共识的资源来定义和测量TCD.
- 这些资源将为早期AD干预提供临床试验选择和分析流程的信息.
- 建立关于TCD的共识对于推进阿尔茨海默病的研究和治疗至关重要.
相关概念视频
01:24Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
01:30Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
01:25Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
01:26Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437