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临床表现 临床表现

Andrew M Kiselica1, Leslie S Gaynor2,3, Kelly J Atkins4,5

  • 1University of Georgia, Athens, GA, USA.

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概括
此摘要是机器生成的。

这项研究提出了Delphi协议来定义早期阿尔茨海默病 (AD) 中的过渡性认知衰退 (TCD). 在TCD命名和测量方面达成共识对于在新的AD诊断标准的第二阶段识别个人至关重要.

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科学领域:

  • 神经科学是一个神经科学.
  • 临床心理学 临床心理学

背景情况:

  • 新的阿尔茨海默病 (AD) 诊断标准包括一个六个阶段的分阶段方案 (1-6).
  • 第二阶段的特点是生物标志物阳性和过渡性认知衰退 (TCD),没有损伤,缺乏明确的临床类比.
  • 关于TCD定义的共识对于早期AD检测和临床试验招募至关重要.

研究的目的:

  • 概述Delphi研究的协议,以建立关于AD中TCD的命名和测量的共识.
  • 确保在新的AD诊断标准的第二阶段准确识别个人.
  • 促进针对AD最早阶段的干预措施的发展.

主要方法:

  • 将进行Delphi共识研究,由具有TCD,Delphi研究和混合方法研究专业知识的指导委员会指导.
  • 一个由大约30名专家组成的小组将被选中参加这项研究.
  • 在线调查将在三轮代中进行,并分析定性反以了解共识驱动因素.

主要成果:

  • 研究协议包括Delphi面板选择,调查开发,重点关注TCD命名和测量,以及代数据收集.
  • 共识将被定义为小组成员之间75%的协议.
  • 将使用定性反来探索影响共识的因素.

结论:

  • 德尔菲研究将产生基于共识的资源来定义和测量TCD.
  • 这些资源将为早期AD干预提供临床试验选择和分析流程的信息.
  • 建立关于TCD的共识对于推进阿尔茨海默病的研究和治疗至关重要.