在社区药房柜台上检测环胺残留物:一个探索性调查
Masato Komuro1,2, Hisanaga Nomura3, Takahito Furuya4
1Department of Medical Informatics, Japan Institute for Health Security, Tokyo, Japan.
The International journal of risk & safety in medicine
|December 26, 2025
概括
在社区药房中发现了环胺污染,表明了潜在的公共卫生风险. 这种污染可能来自患者接触,而不是药房处理或医院CSTD使用.
科学领域:
- 环境健康 环境健康
- 制药科学 制药科学
- 公共卫生 公共卫生
背景情况:
- 环胺 (CP) 是一种危险的化疗剂.
- 通过患者进行危险药物的转移越来越令人担忧.
- 社区药房需要对化疗污染进行评估.
研究的目的:
- 为了评估社区药房柜台上的环胺污染.
- 调查患者间接转移和间接公共卫生风险.
- 检查医院封闭系统传输装置 (CSTD) 使用与污染之间的联系.
主要方法:
- 来自医院附近的24家社区药房的擦拭品样本使用液态染色体质谱分析了环胺.
- 问卷调查评估了CSTD使用和清洁协议.
- 在抽样期间,药房被选为循环胺库存.
主要成果:
- 在20.8%的药房中检测到环胺污染 (5/24).
- 四家受污染的药房没有储存环胺,这表明外部转移.
- 污染发生不论医院使用CSTD或药房处理做法.
结论:
- 药房柜台上的环胺污染可能是患者介导的转移造成的.
- 不能排除库存和包装等替代来源.
- 医院的CSTD可以缓解处理污染,但不能缓解患者介导的途径.
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