临床表现 临床表现
Beili Shao1,2, Abigail Rebecca Lee2, Elizabeta Mukaetova-Ladinska3
1School of Medicine, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
这项研究强调了年轻发病痴呆症诊所中轻度认知障碍 (MCI) 的各种原因,强调了准确诊断对有效治疗的重要性. 阿尔茨海默病是参与者中最常见的诊断.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 轻度认知障碍 (MCI) 代表了正常衰老和痴呆症之间的关键过渡阶段,由于其不同起源和进展,这给诊断带来了挑战.
- 准确的早期诊断和MCI的亚型对于实施向治疗和提供足够的患者和家庭支持至关重要.
研究的目的:
- 为了调查轻度认知障碍 (MCI) 的异质原因和共同病理,个人被转介到专门从事年轻发病痴呆症的区域三级记忆诊所.
- 分析来自潜在纵向队列的人口统计,临床,认知,脑脊液 (CSF) 生物标志物和神经成像数据.
主要方法:
- 在诺丁汉皇后医疗中心进行了一项为期六年的观察性研究 (2018年12月至2024年11月),涉及到被转诊到年轻发病痴呆症诊所的患者.
- 数据收集包括人口统计,临床评估,认知测试 (ACE-III),脑脊液生物标志物和神经成像 (MRI,FDG-PET) 作为神经退行性疾病 (CogNID) 认知和神经成像研究的一部分.
- 分析了429名参与者 (630个推中的68.10%),平均年龄为60.08岁.
主要成果:
- 阿尔茨海默病 (AD) 是最常见的诊断 (24.94%),其次是功能性认知衰退 (12.59%),前性痴呆症 (6.99%),以及COVID相关的认知障碍 (6.06%).
- 在12.82%的参与者中发现了混合病理,AD和前性痴呆 (FTD) 是最常见的同时发生.
- 参与者表现出认知缺陷,特别是在注意力,记忆力和流性方面,脑部MRI是主要的调查方法.
结论:
- 该研究强调了MCI背后的复杂和多样化的病因,在年轻发病痴呆症的背景下.
- 研究结果强调需要全面的诊断方法,包括生物标志物和神经成像分析,以确定共同病理并指导治疗策略.
- 来自记忆诊所的现实数据为MCI及其管理的异质性提供了关键的见解.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437


