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碳烯耐药格拉姆阴性细菌研究的全球趋势 (2020-2025):文献计量分析和系统审查

Xiaotong Zhang^1,2,3, Ce Zhang^1,2,3, Mengyao Lv^1,2,3

¹Department of Infectious Disease, Hebei Medical University Third Hospital, Shijiazhuang, China.

Frontiers in cellular and infection microbiology

|December 26, 2025

概括

耐卡巴尼姆格拉姆阴性细菌 (CRGNB) 的研究正在增长,中国处于领先地位. 关键领域包括耐药机制,新疗法如菌体疗法,以及对CRGNB的AI驱动诊断.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

耐卡巴尼姆的格拉姆阴性细菌 (CRGNB) 代表着一个关键的全球健康挑战.
对CRGNB研究进行全面的文献计量分析是有限的,需要进行系统审查.
本研究旨在绘制2020年至2025年的研究趋势和热点.

研究的目的:

进行CRGNB研究的文献分析.
确定该领域的领先国家,机构和期刊.
绘制研究热点,新兴趋势和合作模式的地图.

主要方法:

从Web of Science核心集合,Scopus和PubMed (2020-2025) 中系统地检索文献.
使用VOSviewer,CiteSpace和Bibliometrix进行图书法分析.
评估出版成果,国家/机构/期刊贡献,以及关键词的同时出现.

主要成果:

全球CRGNB研究显示增长波动,中国是最大的贡献者.
关键的研究集群包括高病毒性菌株 (如K. pneumoniae,E. coli),耐药性机制和新疗法.
新兴优先事项包括人工智能,快速诊断 (基于CRISPR,人工智能驱动的MALDI-TOF) 和非抗生素策略.
对新药 (cefiderocol,sulbactam-durlobactam) 的结果是有希望的,但安全问题仍然存在.

结论:

CRGNB的研究正在转向了解耐药性,提高诊断,并探索非抗生素治疗.
国际合作和多学科方法对于推进CRGNB研究至关重要.
应对CRGNB日益增长的威胁需要持续高质量的研究和战略伙伴关系.

关键词:

在CRGNB的基础上.埃舍里希亚大肠杆菌 (Escherichia coli) 是一个大肠杆菌.抗生素耐药性抗生素耐药性耐卡巴胺的Klebsiella 肺炎菌是耐卡巴胺的碳烯的质量非常大.排放的排放.的突变的突变 β-乳糖酶/β-乳糖酶抑制剂的使用

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