反米勒尔激素对胚胎质量的预测价值在PGT-A周期中的分析分析

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Published on: August 25, 2019

Mengxia Ni¹, Haoting Zhang², Jian Sun¹

¹Center for Reproduction and Genetics, The affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, China.

Frontiers in endocrinology

|December 26, 2025

概括

反米勒尔激素 (AMH) 水平预测了辅助生殖中的胚胎质量. 较高的AMH (>1.68 ng/mL) 与较好的胚胎欧化和较低的阳化率相关,表明胚胎质量得到改善.

科学领域:

生殖内分泌学生殖内分泌学
辅助生殖技术辅助生殖技术
遗传学遗传学是一种遗传学.

背景情况:

抗穆勒尔激素 (AMH) 是辅助生殖中卵巢储备和卵细胞产量的关键指标.
在辅助生殖周期中,AMH对胚胎质量的预测价值仍在调查中.
预植入前遗传测试 (PGT-A) 为评估胚胎质量提供了一个客观的措施.

研究的目的:

调查抗米勒尔激素 (AMH) 水平与胚胎质量之间的关联.
确定AMH是否可以作为PGT-A周期中形积分率的预测指标.
探索患者年龄,体重指数 (BMI) 和胚胎产量对这种关系的影响.

主要方法:

从2018年至2022年的542个PGT-A周期进行了回顾性分析.
患者根据年龄,BMI和可活胚胎数量进行了分层.
使用相关性和逻辑回归分析来评估AMH水平与胚胎积率之间的关系.

主要成果:

亚米水平和euploidy率与可活胚胎数量呈正相关性,而aneuploidy率显示出负相关性.
具有AMH水平>1.68 ng/mL的患者表现出明显更高的euploidy和较低的aneuploidy率.
胚胎质量随着女性年龄的增加而下降,但随着AMH水平的提高和活检胚胎数量的增加,胚胎质量得到改善. 体重指数没有与胚胎质量呈现线性相关性.

结论:

在辅助生殖中,AMH水平是胚胎质量的有价值预测指标.
与≤1.68 ng/mL水平相比,AMH水平>1.68 ng/mL与优越的胚胎质量有关.
虽然AMH与年龄和胚胎产量相关,但BMI不是胚胎质量的独立预测指标.

关键词:

抗穆勒尔激素的激素是反穆勒尔的激素.身体质量指数 (BMI) 是指身体质量指数.胚胎质量胚胎质量女人的年龄女人的年龄植入前遗传性积体的测试

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