两侧关系:对左侧和右侧结直肠癌的单细胞视角
Maria Yanova1, Diana Maltseva1,2, Alexander Tonevitsky1,2
1Faculty of Biology and Biotechnology, National Research University Higher School of Economics, Moscow, Russia.
Frontiers in cell and developmental biology
|December 26, 2025
概括
结肠直肠癌 (CRC) 的侧面性影响了结果. 单细胞测序揭示了独特的左侧 (LCRC) 和右侧 (RCRC) 瘤生态系统,指导未来的向疗法.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 免疫学 免疫学 免疫学
背景情况:
- 结肠直肠癌 (CRC) 是一个主要的全球健康问题.
- 瘤侧向 (左侧与右侧) 影响CRC的预后和治疗反应.
- 左侧CRC (LCRC) 和右侧CRC (RCRC) 之间的基本分子差异尚不清楚.
研究的目的:
- 审查关于CRC异质性的单细胞RNA测序 (sc-seq) 研究.
- 阐明驱动CRC进展,治疗耐药性和转移的细胞和分子机制.
- 突出LCRC和RCRC瘤微环境中的差异.
主要方法:
- 结直肠癌中最近sc-seq研究的综合.
- 恶性,免疫和树皮细胞种群和相互作用的分析.
- 细胞生态系统在LCRC与RCRC之间的比较.
主要成果:
- Sc-seq显示出明显的恶性子集群,具有代谢重编程和瘤信号.
- 识别影响瘤免疫力的专门免疫细胞状态 (巨细胞,T细胞,巨细胞).
- 描述涉及矩阵重塑,血管生成和免疫逃逸的 stromal 组件 (纤维细胞,内皮细胞).
- 证明LCRC和RCRC是不同的多细胞生态系统,具有差异性的免疫和结构信号.
结论:
- LCRC和RCRC表现出独特的细胞和分子特征.
- 准细胞间通信和瘤微环境相互作用至关重要.
- 需要基于偏见的治疗策略来改善CRC的结果.
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