决策和执行功能在自杀思想和行为中的神经相关性
Fangfang Tian1, Lu Zhou2, Xiuli Wang3
1Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in psychiatry
|December 26, 2025
概括
精神病患者有自杀的想法和行为表现出与决策和执行功能相关的区域的大脑活动发生变化. 前带带皮层的异常与自杀风险有关,这表明有针对性的干预措施.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 在精神病患者中调查决策 (DM) 和执行功能 (EF) 的神经支柱,这些患者有自杀想法和行为 (STB).
- 了解与性传播疾病相关的大脑变化对于开发有效干预措施至关重要.
研究的目的:
- 在患有性病的个体中,在DM和EF任务期间识别异常神经活动的特定大脑区域.
- 探索DM和EF缺陷在自杀行为病理生理学的作用.
主要方法:
- 在PubMed,ScienceDirect和Web of Science进行系统的文献搜索.
- 基于定量坐标的元分析,使用基于种子的d映射 (ASE-SDM) 的异型效应尺寸版本.
- 多模式分析,以调查神经相关物,与灵敏度分析和出版偏差评估的稳定性.
主要成果:
- 患有STB的患者在DM任务中表现出左侧前带带皮层 (ACC) 和右侧胰岛的过激活,以及左侧胰岛和左侧海马体的低激活.
- 在EF任务中,患有STB的患者在左侧ACC和左前中心中表现出过度激活.
- 多模式分析证实了带带皮质在DM和EF过程中的重要作用.
结论:
- 在ACC中失调的神经活动是导致自杀风险的关键机制.
- 决策异常似乎比执行功能缺陷更为关键的自杀风险.
- 结果表明潜在的治疗目标,包括认知行为疗法和基于正念的干预措施,专注于左侧ACC和情绪调节.
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