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在瘤进展和治疗中的癌细胞记忆的机械调节

Yunjia Qu¹, Jiaxin Cui¹, Zhuohang Wu¹

¹The Alfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.

Mechanobiology in medicine

|December 26, 2025

概括

癌细胞的记忆,由瘤微环境中的机械线索驱动,促进瘤的进展和治疗耐药性. 通过机械准策略重新连接这种记忆,为治疗提供了新的途径.

科学领域:

癌症生物学癌症生物学
机械生物学机械生物学
瘤微环境研究研究

背景情况:

癌细胞的记忆,保留对刺激的反应,驱动瘤的进展,治疗耐药性和免疫逃避.
瘤微环境 (TME) 中的机械线索 (矩阵刚性,粘弹性,应力) 是癌细胞记忆的关键调节者.
生物物理输入诱导持久的转录,表观遗传和表型变化,促进侵袭性癌症特征.

研究的目的:

审查机械生物学在塑造癌细胞记忆中的作用.
总结一下细胞外矩阵 (ECM) 如何将机械输入编码为基因表达程序.
要突出机械调节的可塑性和表观遗传变化,控制耐药性和治疗失败.

主要方法:

关于机械生物学和癌细胞记忆的当前文献的综述.
分析ECM组合和改造如何影响机械线索.
检查机械调节的细胞过程,如可塑性,膜张力和染色质重塑.

主要成果:

ECM组合和重塑将机械输入转化为稳定的基因表达程序,促进瘤的进展.
机械调节的可塑性,膜张力,染色质重塑和表观遗传修饰控制癌细胞的自我更新,分化和抵抗力.
通过TME进行物理抑制对化疗,放射治疗和向治疗的失败有很大影响.

结论:

机械生物学在建立和维护癌细胞记忆中发挥着关键作用.
新兴的机械向策略,包括ECM降解剂和度响应纳米颗粒,对重新连接癌细胞记忆充满希望.
针对TME的物理性质提供了一种新的方法来克服治疗耐药性并改善癌症治疗结果.

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