在患有非小细胞肺癌的患者中预测肺栓塞的诺莫грам的开发和验证
1Xiaoting Wu, Department of Respiratory and Critical Care, First People's Hospital of Linping District, Hangzhou, Zhejiang Province 311199, P.R. China.
Pakistan journal of medical sciences
|December 26, 2025
概括
这项研究开发了一种名谱,用于预测非小细胞肺癌 (NSCLC) 患者的肺栓塞 (PE) 风险. 该模型准确地识别了临床查的高风险个体.
科学领域:
- 在瘤学瘤学.
- 肺部医学 肺部医学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 非小细胞肺癌 (NSCLC) 患者经常经历复杂的临床表现和诊断挑战,当肺栓塞 (PE) 复杂时.
- 在NSCLC中精确的PE风险分层对于及时干预和改善患者结果至关重要.
研究的目的:
- 开发和验证一个个性化的诺姆图,用于预测非小细胞肺癌患者肺栓塞风险.
- 确定与NSCLC中PE发展相关的关键临床和实验室因素.
主要方法:
- 追溯分析了390名NSCLC患者的队列.
- 最小绝对收缩和选择运营商 (LASSO) 和多变量后勤回归确定了独立的风险因素.
- 使用接收机操作特征 (ROC) 曲线,校准图表和决策曲线分析 (DCA) 验证了模型性能.
主要成果:
- 在参加的NSCLC患者中,有89人 (22.8%) 患有肺栓塞.
- 确定了PE的七个独立风险因素:病理类型,TNM分期,中央静脉导管使用,化疗,血红蛋白,白细胞计数 (WBC) 和中性粒细胞与淋巴细胞比率 (NLR).
- 开发的诺米图表表现出强大的预测能力,AUC为0.909,并具有良好的校准.
结论:
- 个性化的诺米图表显示了在NSCLC患者中PE风险的优异预测性能.
- 这种工具有可能帮助临床查高风险NSCLC患者的肺栓塞.
更多相关视频
相关概念视频
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
274
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
274
Dosage Regimen Designs: Nomograms and Tabulations
152
Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
152
Pulmonary Embolism III: Nursing Management
315
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
315
Pulmonary Embolism I: Introduction
459
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
459


