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危急病患者中抗卡巴胺生物体的经济负担:一个多中心,回顾性队列研究

Wenjing Jiang^1,2, Min Feng³, Li Cao²

¹Department of Nursing, Sichuan Vocational College of Health and Rehabilitation, Zigong, People's Republic of China.

Infection and drug resistance

|December 26, 2025

概括

碳烯耐药生物 (CROs) 在中国显著增加了ICU停留时间和住院费用. 早期查和预防策略对于减轻CROs的经济负担至关重要.

科学领域:

传染性疾病传染性疾病
卫生经济学卫生经济学
关键护理医学关键护理医学

背景情况:

耐卡巴胺生物体 (CROs) 构成了严重的全球健康威胁,特别是在重症监护室 (ICU).
与CRO相关的有限的治疗选择和高发病率/死亡率需要充分了解其临床和经济影响.
虽然研究了临床影响,但对CROs经济负担的系统定量仍未得到充分研究.

研究的目的:

评估与卡巴胺敏感生物 (CSO) 相比,CROs所承受的经济负担.
评估CRO对中国重症患者医疗保健资源利用的影响.

主要方法:

对来自中国西部两个三级医院的7232名ICU患者进行了回顾性队列研究 (2019-2024年).
倾向性得分匹配 (1:1) 来比较患者与CRO与CSO.
使用通用线性模型 (GLM) 分析了ICU停留时间 (LOS),医院LOS,住院总成本和机构机会成本.

主要成果:

在5.24%的患者中发现了CRO,主要的病原体是耐卡巴胺的Acinetobacter baumannii (CRAB).
与CSO组相比,CRO组的ICU LOS (11.0 vs 5.0天),医院LOS (24.0 vs 13.0天) 和总住院费用 (CNY 99,549 vs CNY 50,279) 显著更长 (所有人P<0.001).
独立预测CRO状态增加了ICU LOS,医院 LOS和总成本. 由于CRO患者的病床占用过多,估计每年的机构财务损失约为134,000元人民币.

结论:

CRO感染与ICU患者的经济负担大幅增加有关.
调查结果强调了实施早期查和有针对性的预防策略的重要性.
抗微生物管理计划对于减轻CROs的临床和经济影响至关重要.

关键词:

CROs 是一个CRO.在 GLM 里面.在ICU中,医生会对患者进行治疗.公共服务管理 (PSM)耐卡巴胺的生物体经济负担经济负担一般化的线性模型.住院费用住院费用住院费用重症监护病房是重症监护病房.停留时间的长度.倾向性得分匹配的比分匹配

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