用苏克拉取代添加糖对亚洲印第安人成年人肠道微生物组合的影响在两项为期12周的随机对照试验中
Danielle E Haslam1,2, Kuzhandaivelu Abirami3, Jacqueline R Starr1
1Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Current developments in nutrition
|December 26, 2025
概括
在饮料中取代糖的糖改变了亚洲印第安人2型糖尿病成年人的肠道细菌,但不是那些超重或肥胖的人. 这些发现突出了对肠道微生物组的组成和功能的潜在影响.
科学领域:
- 微生物组研究的研究.
- 人类营养人类营养
- 代谢健康 代谢健康
背景情况:
- 像苏克拉这样的非营养甜味剂可能有助于体重控制,但由于排泄到便中,可以改变肠道微生物群.
- 糖消费对肠道微生物组成的影响需要进一步研究,特别是在多样化的群体中.
研究的目的:
- 为了研究糖对亚洲印第安人成年人2型糖尿病 (T2D) 或超重/肥胖的肠道微生物群的影响.
- 为了比较饮料中的糖糖被糖糖糖替换时的微生物组变化,与持续的糖糖消费相比.
主要方法:
- 两项为期12周的随机对照试验,涉及患有T2D的成年人 (n=49) 或没有T2D的超重/肥胖者 (n=48).
- 参与者用糖取代了糖,或继续在每天的咖啡和茶中加入糖.
- 用便样本的16S rRNA测序分析了肠道微生物群体的结构和组成.
主要成果:
- 在患有T2D的成年人中,糖干预减少了肠道微生物群的α多样性,增加了β多样性 (P<0.05).
- 在T2D参与者中的特定细菌变化包括糖发酵Firmicutes的丰富性减少和Enterococcus和Pediococcus的增加.
- 在没有T2D的超重/肥胖成年人中没有观察到显著的肠道微生物组变化.
结论:
- 在饮料中用糖取代糖会改变亚洲印第安人T2D成年人的肠道微生物组合.
- 没有T2D的超重/肥胖成人肠道微生物组没有受到糖替代的显著影响.
- 需要进一步的研究来阐明这些观察到的微生物组变化背后的健康影响和机制.
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