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Updated: Jan 7, 2026

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
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在现场释放的细菌膜囊泡激活了STING通路,通过增强免疫治疗的细胞内DNA池

Wenjie Wang1,2, Anjun Song1,2, Fang Pu1,2

  • 1Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun Jilin 130022 P. R. China jren@ciac.ac.cn xqu@ciac.ac.cn.

Chemical science
|December 26, 2025
PubMed
概括

这项研究开发了一种新型的纳米平台,可以增强干扰素基因 (STING) 途径的循环氨酸单酸-氨酸单酸合成酶 (cGAS) 刺激器. 这种方法通过增加细胞内DNA来增强癌症免疫治疗的免疫反应.

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