LOGSAGE:基于日志的性用于指导编码在坚固的核中 免疫光组织学图像的细分
Sahar A Mohammed1, Siyavash Shabani1, Muhammad Sohaib1
1Department of Electrical and Biomedical Engineering, University of Nevada, Reno (UNR).
Proceedings. IEEE International Symposium on Biomedical Imaging
|December 26, 2025
概括
准确细分瘤微环境 (TME) 是一个挑战. LoGSAGE-Net是一种新的深度学习模型,改进了TME图像细分,用于更好的癌症研究和敏感测试.
科学领域:
- 计算生物学是一种计算生物学.
- 医学成像分析分析 医学成像分析
- 癌症研究 癌症研究
背景情况:
- 瘤微环境 (TME) 对癌症的进展和治疗反应至关重要.
- 在免疫光 (IF) 图像中精确细分TME细胞架构是复杂和具有挑战性的.
研究的目的:
- 引入LoGSAGE-Net,这是一种用于增强免疫光成像细分的新型深度学习模型.
- 为了提高瘤微环境概况的准确性和稳定性.
主要方法:
- 开发了LoGSAGE-Net,将Swin变压器与高斯 (LoG) 突出性的拉普拉西亚连接起来.
- 将子和曲率对齐损失纳入模型的损失函数中.
- 将模型应用于大量临床前免疫光数据队列.
主要成果:
- 与最先进的方法相比,LoGSAGE-Net表现出更高的性能.
- 在图像细分方面获得了94.92%的高子得分.
- 获得了81%的全视质量 (PQ) 评分,表明了出色的细分和分类.
结论:
- LoGSAGE-Net提供了一个强大的解决方案,用于分割复杂的TME图像.
- 该模型促进了准确的TME分析,支持开发敏感的诊断和治疗试验.
- 这一进步有助于了解癌症的进展和治疗反应.
相关概念视频
01:18Imaging Biological Samples with Optical Microscopy
Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
01:12Immunofluorescence Microscopy
A fluorescence microscope uses fluorescent chromophores called fluorochromes, which can absorb energy from a light source and then emit this energy as visible light. Fluorochromes include naturally fluorescent substances (such as chlorophylls) and fluorescent stains that are added to the specimen to create contrast. Dyes such as Texas red and FITC are examples of fluorochromes. Other examples include the nucleic acid dyes 4’,6’-diamidino-2-phenylindole (DAPI), and acridine orange.
The...
The...