在怀孕期间大脑类型性尿素 (BNP) 水平的有用性
Stuart Quek1, Rabia Zill-E-Huma2, Mark Andrews3
1Manchester University Hospital NHS Foundation Trust, Manchester, UK.
大脑类型的性尿素 (BNP) 和NT-proBNP对于诊断怀孕期间的心脏问题,包括先兆子和心力衰竭是有价值的. 宝宝血水平可以准确预测心脏并发症,有助于对不良妊娠结果的风险分层.
科学领域:
- 心脏病学 心脏病学
- 产科 产科 产科 产科 产科
- 生物标志物 生物标志物
背景情况:
- 性尿素,包括大脑型性尿素 (BNP) 和N终端亲B型性尿素 (NT-proBNP),是心脏分泌的激素.
- 怀孕期间的生理变化增加了BNP分泌.
- 虽然已被确立用于非怀孕个体的心力衰竭诊断,但它们在怀孕中的实用性不那么明确.
研究的目的:
- 总结关于BNP在怀孕中的潜在用途的文献.
- 探索BNP在怀孕期间心血管风险评估中的作用.
主要方法:
- 通过使用Medline,PubMed,Cochrane控制试验中央注册表和Cochrane系统审查数据库进行了系统的文献搜索.
- 包括以英语语言的研究,重点关注BNP和怀孕.
主要成果:
- 在怀孕期间,BNP和NT-proBNP有效地诊断和预测心脏并发症,如心力衰竭,子宫前和围产期心肌病.
- 确定了跨季度BNP和NT-proBNP的建议上限.
- 超过100ppg/ml的BNP水平显示了对心脏并发症的高诊断准确性 (98%的灵敏度,92%的特异性).
- 将BNP与sFlt-1/PlGF比率相结合,改善了对子前分娩的预测.
结论:
- 在怀孕期间诊断和分层心脏风险方面,BNP和NT-proBNP是有价值的.
- 需要进一步的研究,以确定可靠的BNP截止值,考虑到先前存在的疾病和肥胖等因素.
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