患有酒精使用障碍的MASLD患者的临床结果
1Digestive Disease Research Center, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 908, Charleston, SC 29425 USA.
Journal of diabetes and metabolic disorders
|December 26, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 和酒精使用障碍 (AUD) 患者面临更糟糕的结果. 与单独使用MASLD相比,这种组合增加了主要的不良心血管事件和死亡率.
科学领域:
- 肝病学和胃肠病学 肝病学和胃肠学
- 心血管医学 心血管医学
- 成 药物 药物 药物 药物
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
- MASLD和酒精使用障碍 (AUD) 之间的相互作用需要进一步调查疾病进展和患者的结果.
研究的目的:
- 评估同时存在的酒精使用障碍 (AUD) 对代谢功能障碍相关的脂肪性肝病 (MASLD) 患者肝病进展的影响.
- 为了比较单独患有MASLD,患有AUD的MASLD和与酒精有关的肝病 (ALD) 的患者之间的结果.
主要方法:
- 利用TrinetX分析网络分析了患有MASLD,AUD和/或ALD的成年患者的数据.
- 雇员倾向性得分匹配 (PSM) 用于比较MASLD/AUD患者与单独MASLD患者的结果.
- 评估了与肝脏相关的脱补偿事件,主要不良心血管事件 (MACE) 和全因死亡率作为主要和次要结局.
主要成果:
- 确定了大量患有MASLD的患者队列 (n=668,264),包括单独患有MASLD,MASLD/AUD和ALD的子组.
- 与单独使用MASLD相比,MASLD/AUD患者的肝衰减率 (13%与7%相比),MACE (21%与17%) 和全因死亡率 (14%与8%) 显著增加.
- 后PSM分析证实,MASLD/AUD与MACE的23%增加和整体死亡率的34%增加相比,单独使用MASLD.
结论:
- 马斯尔德和AUD的同时出现代表了一个独特的高风险表型.
- 与单独使用MASLD相比,MASLD/AUD与明显更差的临床结果有关,包括肝病进展和死亡率的增加.
- 心血管负担的显著增加强调了MASLD/AUD重叠的严重性.
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