患有早期阿尔茨海默病 (EOAD) 的患者的种族差异
Meredith Yang1, Suemin Jasmine Yoon2, Kristen Taruc3
1Pritzker School of Medicine, University of Chicago, Chicago, IL, United States.
Frontiers in neurology
|December 26, 2025
概括
患有早期阿尔茨海默氏症 (EOAD) 的黑人患者比白人患者面临更长的诊断延迟和更先进的疾病. 这项研究强调了EOAD诊断和表现中的种族差异.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 公共卫生 公共卫生
背景情况:
- 在早期发病的阿尔茨海默氏症 (EOAD) 中的种族差异尚未得到充分理解.
- 描述这些差异对于公平的医疗保健至关重要.
- 之前的研究还没有完全详细说明EOAD的种族差异.
研究的目的:
- 在早期发病的阿尔茨海默氏症中调查和描述种族差异.
- 为了比较黑色和白色EOAD患者之间的诊断时间表和临床表现.
- 确定少数群体诊断过程中的潜在障碍或差异.
主要方法:
- 在2017年2月至2022年2月期间诊断的81名早期阿尔茨海默病患者的回顾性队列研究.
- 分析了患者数据,包括诊断时的年龄,诊断时间和认知评估得分.
- 人口统计信息,特别是种族 (黑人与白人),被用来比较患者群体.
主要成果:
- 该队列包括53名白人 (65.4%) 和28名黑人 (34.6%) 患者.
- 与白人患者 (2.64年) 相比,黑人患者的诊断时间更长 (3.39年).
- 与白人患者相比,黑人患者的MOCA分数较低 (12.17) 并且有更高的amnestic概况 (67.9%).
结论:
- 在这个队列中,患有EOAD的黑人患者的平均年龄较大,病情更晚.
- 与白人患者相比,在黑人患者中观察到诊断的显著延迟.
- 研究结果强调,需要解决早期阿尔茨海默病的诊断和管理方面的种族差异.
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