临床表现 临床表现
Siddharth Nayak1, Mark E Wagshul1, Roee Holtzer2
1Albert Einstein College of Medicine, New York, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
轻度认知障碍 (MCI) 对老年人影响大脑网络和认知功能. 了解这些变化对于早期发现阿尔茨海默病和干预策略至关重要.
科学领域:
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
- 老年学是一门学科.
背景情况:
- 阿尔茨海默病 (AD) 的研究重点是临床前阶段,特别是从正常衰老过渡到轻度认知障碍 (MCI).
- 描述MCI和没有MCI的大脑认知关联对于理解早期AD病理生理学至关重要.
- 这项研究调查了老年人的功能性脑网络变化,考虑到MCI状态.
研究的目的:
- 为了检查轻度认知障碍 (MCI) 如何影响老年人的大脑行为关系.
- 在患有或没有MCI的个体中识别与认知处理速度 (符号数字模式测试 (SDMT)) 相关的特定大脑网络.
- 在阿尔茨海默病的临床前阶段探索功能连接模式.
主要方法:
- 167名老年人 (82名患有多发性硬化症,85名对照人) 接受了休息状态功能性MRI (rsfMRI) 和结构性MRI.
- 组独立组件分析 (ICA) 确定了大脑网络,通过双回归推导出特定对象的表达式.
- 多个线性回归分析了网络表达分数和SDMT性能之间的关联.
主要成果:
- 在总样本中,SMN,LFPN和突出网络与SDMT性能有关.
- 在MS患者中,SMN和中间视觉网络与SDMT相关;对照组中没有发现显著的关联.
- 当排除MCI参与者时,LFPN和RFPN网络显示与SDMT的关联. 在没有MCI的对照中,RFPN,LFPN和突出网络与SDMT有关.
结论:
- 在老年人中,MCI状态显著影响大脑认知关联.
- 这些发现突出了阿尔茨海默病临床前阶段功能连接的动态变化.
- 这项研究为早期AD检测提供了对神经生物学标记的洞察.
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