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临床表现 临床表现

Timothy J Herron1, Jas M Chok1,2, Sandy J Lwi1

  • 1Veterans Affairs Northern California Health Care System, Martinez, CA, USA.

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概括
此摘要是机器生成的。

来自加利福尼亚认知评估电池 (CCAB) 的新认知因素与健康老年人的主观记忆抱怨相关. 这些因素可能是认知能力下降的早期标志物.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 认知心理学 认知心理学

背景情况:

  • 痴呆症治疗的进步需要早期认知衰退的敏感标志物.
  • 在健康的老年人中早期识别认知衰退至关重要.
  • 主观认知投诉是早期衰退的潜在指标.

研究的目的:

  • 从计算机电池评估初级和二级认知测试指标的实用性,以识别早期认知衰退.
  • 探索新的认知因素和主观认知投诉之间的关系.
  • 在对认知健康的老年参与者的纵向研究中评估认知标志物.

主要方法:

  • 309名认知健康的老年人使用加利福尼亚认知评估电池 (CCAB) 在30个月内进行了评估.
  • 传统的聚合因子和新的认知因子 (包括二级指标) 来自CCAB分数.
  • 线性混合模型 (LMM) 和隐性类混合模型 (LCMM) 用于分析纵向数据,并将认知因素与主观记忆抱怨 (认知失败问卷 - CFQ) 进行比较.

主要成果:

  • 新的因素 (记忆,视觉空间/执行,偶然的速度) 和传统的PACC-R因子与升高的CFQ分数显著相关.
  • 在30个月的时间里,在 CFQ 和测试学习或因子下降之间没有发现显著的相互作用.
  • 在LCMM分析中,结果各不相同;其中一种方法根据词汇,年龄和种族对受试者进行分类,与CFQ的相关性较弱.

结论:

  • 来自CCAB的新型认知因素与遗忘症等主观认知投诉有关.
  • 这些新的认知标志物显示出作为认知衰退早期指标的潜力.
  • 在不同的人群和临床环境 (例如,轻度认知障碍) 中进行进一步的验证正在进行中.