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临床表现 临床表现

Kristen E Kehl-Floberg1, Aurora Pop-Vicas1, Dorothy F Edwards2,3

  • 1University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.

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概括
此摘要是机器生成的。

自我报告的认知功能,通过PROMIS认知功能得分来衡量,显著预测长期COVID. 低得分与经历长期COVID症状的几率增加了5到6倍.

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科学领域:

  • 神经科学是一个神经科学.
  • 公共卫生 公共卫生
  • 传染性疾病 传染性疾病

背景情况:

  • 长期COVID的特点是衰弱的神经认知症状,通常被称为"脑雾".
  • 现有的神经认知查工具不足以检测COVID后的认知障碍.
  • 对长期COVID患者进行认知功能障碍的有效查对于临床管理至关重要.

研究的目的:

  • 为了比较自我报告的认知功能与长期COVID状态的神经心理测试之间的关联.
  • 确定在持久性后COVID症状的个体中认知障碍的可靠查方法.

主要方法:

  • 一项横截面队列研究分析了长期COVID的174名参与者 (67例,107例对照).
  • 二元逻辑回归模拟了使用MoCA (蒙特利尔认知评估) 分数和PROMIS (患者报告结果测量信息系统) 8项认知功能t分数的长COVID状态.
  • 对年龄进行控制的分析,并纳入了MoCA切割分数的种族/种族权重.

主要成果:

  • 低PROMIS认知功能得分 (下四分之一为36.67) 显著增加了长期COVID的几率,在各个年龄组中增加了5到7倍,即使是"非受损"的MoCA得分.
  • 根据种族/种族加权的MoCA切割分数在任何年龄段都不能显著预测长期COVID状态.
  • 普罗米斯认知功能的得分与长期COVID有着强有力的关联,独立于年龄和MoCA表现.

结论:

  • 自我报告的PROMIS认知功能得分是长期COVID的强有力的预测指标.
  • 这些自评分比传统的MoCA评估更有效地识别与长期COVID相关的认知功能障碍.
  • 普罗米斯认知功能提供了一个敏感的工具,用于查和评估后COVID条件的认知影响.