在有症状的手性骨关节炎中胆汁酸代谢
Jiatian Li1, Jing Ye1, Tuo Yang2
1Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Arthritis & rheumatology (Hoboken, N.J.)
|December 26, 2025
概括
脱氧胆酸 (DCA) 水平升高与手部症状性骨关节炎 (SHOA) 有关. DCA与肠道微生物相互作用,这表明它在SHOA的发展和潜在的治疗点中发挥了作用.
科学领域:
- 胃肠病学和肝病学
- 类风湿病学 类风湿病学
- 微生物组研究 微生物组研究
背景情况:
- 肠道微生物组失调与手部症状性骨关节炎 (SHOA) 有关.
- 胆酸 (BAs) 是宿主微生物群相互作用中的关键代谢物,但它们在SHOA中的作用尚不清楚.
研究的目的:
- 调查血BA代谢与SHOA之间的关联.
- 探索肠道微生物,BA和SHOA之间的相互作用.
主要方法:
- 后勤回归模型分析了两个队列中的血BA和SHOA.
- 综合肠道微生物组数据,以评估微生物与BA的关联.
- 基于基因的探索性元分析检查了BA受体基因和手部OA.
主要成果:
- 在发现队列 (n=1,359) 中,增加的脱氧醇酸 (DCA) 种类和DCA水平与SHOA的存在和严重程度有关,并在独立队列 (n=142) 中得到验证.
- 多omics分析揭示了DCA,DCA物种/总BA比率和SHOA相关的肠道微生物之间的相关性.
- DCA与SHOA相关的肠道微生物相互作用,编码FXR和PXR受体的基因与手部OA有关.
结论:
- 不调节的BA代谢,特别是增加的DCA水平,与SHOA有关.
- DCA与肠道微生物之间的相互作用,以及BA受体基因关联,为SHOA的未来研究和治疗策略提供了潜在的途径.
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