对化微生物衍生溶解有机的分析:将分子结构与毒理风险联系起来
Qian Hu1, Mengfei Bi1, He Guo2
1Key Laboratory of Plant Nutrition and the Agri-Environment in Northwest China, Ministry of Agriculture, State Key Laboratory of Soil and Water Conservation and Desertification Control, College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi Province 712100, China.
溶解有机 (DON) 源,如可溶性微生物产品 (SMP) 和细胞外聚合物物质 (EPS),在水化过程中形成不同的消毒副产品 (N-DBPs),影响水安全.
科学领域:
- 环境化学环境化学
- 水处理技术水处理技术
- 毒理学 毒理学 毒理学
背景情况:
- 溶解有机 (DON) 是化消毒副产品 (N-DBPs) 的关键前体.
- 可溶性微生物产品 (SMP) 和细胞外聚合物物质 (EPS) 是水生环境中重要的DON来源.
- 了解DON成分对N-DBP形成的影响对于水安全至关重要.
研究的目的:
- 系统地探索SMP和EPS的化反应网络.
- 阐明生成的N-DBPs的结构和毒理学概况.
- 为了比较不同DON来源的N-DBP形成路径.
主要方法:
- 化SMP和EPS的方法.
- 分子网络分析.
- 超高性能液态染色学-高分辨率质谱学 (UHPLC-HRMS).
主要成果:
- 具有较高芳香度的SMP,优先通过电友芳香替代形成芳香化DBPs (Cl-DBPs).
- 富含可变蛋白质的EPS通过蛋白质和脂质化促进了N-DBP生成.
- 确定了两个主要的N-DBP类别:有毒的异环芳氨酸和较少有毒的长链阿里法氨酸.
结论:
- 不同的DON源 (SMP与EPS) 会导致不同的N-DBP形成路径.
- 来自SMP的芳香Cl-DBPs和来自EPS的N-DBPs具有不同的毒理风险.
- 多个终点毒性评估对于评估含有DON丰富的化水中的水质至关重要.
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