生物标志物 生物标志物
Sinthujah Vigneswaran1,2,3, Inge M W Verberk4, Lynn Boonkamp5
1Alzheimer Center, Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
基于血液的生物标志物 (BBM) 提高了神经退行性疾病的诊断信心. 这个小组在记忆诊所中显示了附加值,有助于在少数患者的诊断.
科学领域:
- 神经学 神经学
- 生物标志物研究 生物标志物研究
- 临床诊断 临床诊断 临床诊断
背景情况:
- 基于血液的生物标志物 (BBM) 为诊断神经退行性疾病提供了一种最少的侵入性方法.
- 在广泛采用之前,评估BBM面板在记忆诊所患者中的实际临床有效性至关重要.
研究的目的:
- 预期评估一个定制的BBM小组对综合症诊断,疑似病因和诊断信心的影响.
- 为了确定BBM的临床实用性,结果是在现实世界的记忆诊所环境中.
主要方法:
- 450名患者接受了标准化诊断工作,包括BBM面板 (血pTau181,GFAP,NfL).
- BBM结果是根据差异诊断量身定制的,并在初步临床评估后披露.
- 在BBM披露之前和之后评估了综合征诊断,疑似病因和诊断信心.
主要成果:
- 在BBM披露后,诊断信心的中位数显著从80%增加到90% (p < 0.001).
- 综合征诊断在1%的患者中被修改,可疑病因在5%的患者中被改变.
- 在疑似阿尔茨海默氏病 (AD) 的患者中,36%的患者根据BBM小组被归类为AD的高概率.
结论:
- 根据个人诊断考虑量身定制的BBM小组增加了诊断信心.
- BBM小组在日常临床实践中展示了附加值,影响了少数患者的诊断.
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