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临床表现 临床表现

Jonathan Adrian Zegarra-Valdivia1, Milagros Del Rocio Casimiro-Arana1, Leandro Aron Perez-Fernandez1

  • 1Universidad Señor de Sipán, Chiclayo, Peru.

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概括
此摘要是机器生成的。

这项研究揭示了阿尔茨海默病 (AD) 患者与秘鲁对照人群相比,在阿尔茨海默病 (AD) 患者的认知和执行能力明显受损. 像RUDAS和INECO这样的标准化评估对于识别神经认知衰退至关重要.

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科学领域:

  • 神经科学是一个神经科学.
  • 认知心理学 认知心理学
  • 公共卫生 公共卫生

背景情况:

  • 轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 是一种进展性神经退行性疾病,影响认知和日常生活.
  • 这是秘鲁首次使用标准化神经心理学仪器评估MCI和AD患者的认知表现的多站点研究.
  • 这项研究旨在通过在多个秘鲁城市进行全面的神经心理评估来描述患有MCI和AD的参与者.

研究的目的:

  • 在秘鲁,对患有轻度认知障碍 (MCI) 和阿尔茨海默氏症 (AD) 患者的认知表现进行表征.
  • 评估标准化神经心理仪器在区分这些条件中的有效性.
  • 在秘鲁背景下,提供对痴呆症评估和早期识别策略的见解.

主要方法:

  • 总共有267名参与者被评估:145人为对照组,41人患有MCI,81人患有AD.
  • 标准化的评估包括PHQ-9,Pfeffer,RUDAS和INECO.
  • 在使用T-Student或Mann-Whitney U统计测试的组之间比较了RUDAS和INECO分数.

主要成果:

  • 与对照组相比,阿尔茨海默氏病 (AD) 患者表现出显著的认知和执行功能障碍.
  • 在AD患者 (11.26±8.3) 和对照组 (26.61±3.1),p<0.001) 中,RUDAS总分显著较低.
  • 在与抑制控制和工作记忆有关的INECO子测试中,AD患者表现出损伤,特别是Instrucciones Conflictivas (p < 0.001) 和Meses Atrás (p = 0.018).

结论:

  • 研究结果证实,与MCI和对照组相比,阿尔茨海默病患者的认知和执行能力严重受损.
  • 鲁达斯和INECO评分显示了在分辨神经认知状况方面的潜力,突出了AD中抑制控制和工作记忆的缺陷.
  • 这项研究为秘鲁痴呆症评估提供了新的见解,强调了标准化评估对早期认知衰退检测的重要性.