在T2DM患者中,低心脏代谢指数和腹功能障碍之间存在关联HFpEF
V Y Susanti1, I M Adhikara2, D B Nugroho2
1Division of Endocrinology and Metabolic Disease, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito Hospital, Indonesia. vinayantisusanti@ugm.ac.id.
The Medical journal of Malaysia
|December 26, 2025
概括
较低的心脏代谢指数 (TG/FBG,TG/HDL-C,LDL-C/HDL-C) 与2型糖尿病 (T2DM) 患者的心力衰竭与保留喷射小部分 (HFpEF) 的腹痛功能障碍有关. 优化这些标志物可能会防止HFpEF的进展.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 低心脏代谢指数 (TG/FBG,TG/HDL-C,LDL-C/HDL-C) 显示的脱脂症会增加糖尿病心肌病的风险.
- 2型糖尿病 (T2DM) 通过透支功能障碍与心脏衰竭与保存喷射率 (HFpEF) 有关.
- 在T2DM患者中,心脏代谢指数与腹功能障碍之间的独立关联需要进行研究.
研究的目的:
- 为了研究心脏代谢指数 (TG/FBG,TG/HDL-C,LDL-C/HDL-C) 与腹功能障碍之间的关联.
- 探索诊断为HFpEF的T2DM患者之间的关系.
主要方法:
- 从2021年10月到2022年1月进行电子病历分析的横截面研究.
- 包括55名具有临床HFpEF的T2DM患者.
- 分析基线特征,实验室变量,药物和心声回声数据;使用曼-惠特尼分析.
主要成果:
- 在T2DM患有HFpEF的患者中,透支功能障碍与与正常透支功能患者相比显著较低的中位数TG/FBG (p=0.015),TG/HDL-C (p=0.003) 和LDL-C/HDL-C (p=0.044) 相关.
- 研究结果表明,较低的心脏代谢指数与心室放松受损之间存在矛盾的联系.
结论:
- TG/FBG,TG/HDL-C和LDL-C/HDL-C与T2DM患有HFpEF的患者的舒张功能障碍有显著的相关性.
- 通过更高的心脏代谢指数来表明,保持最佳的脂质失调控制可能是防止T2DM中HFpEF进展的策略.
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