患有赫尔施普朗格病的儿童肠道微生物组合的变化:与健康对照组进行比较研究
M Makkadafi1, W Warsinggih2, S As'ad3
1Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. munamakkadafi@gmail.com.
The Medical journal of Malaysia
|December 26, 2025
概括
患有赫施普隆病 (HSCR) 的儿童有改变的肠道细菌,显示出较少的有益微生物和更多的有害微生物,如肠杆菌. 这种失生症可能为HSCR提供新的治疗点.
科学领域:
- 微生物学 微生物学
- 儿科胃肠病学 儿科胃肠病学
- 遗传学 遗传学 是一个
背景情况:
- 赫施普隆病 (HSCR) 是一种先天性疾病,影响结肠的神经,导致肠道阻塞.
- 肠道微生物组在HSCR病原发生中的作用尚不清楚.
- 研究HSCR中的微生物变化对于了解疾病机制至关重要.
研究的目的:
- 为了描述便微生物群的组成,在儿童与希尔施普朗格病.
- 为了比较HSCR患者的微生物群与健康对照群的微生物群.
- 为了确定与HSCR相关的潜在微生物生物标志物.
主要方法:
- 一项涉及7名手术前HSCR患者和3名健康对照者的比较横截面研究.
- 使用16S rRNA基因测序来分析便微生物群的组成.
- 收集了临床数据,包括营养状况和药物 anamnesis.
主要成果:
- 与对照组相比,HSCR患者的Enterobacteriaceae增加了11倍.
- 在HSCR患者中观察到有益细菌 (例如Lactobacillus,Bifidobacterium) 的减少.
- 发现了潜在的致病细菌 (例如,Escherichia-Shigella) 的增加和Firmicutes和Actinobacteria的减少.
结论:
- 患有HSCR的儿童表现出明显的肠道失生症,其特点是有益细菌减少,肠道细菌增加.
- 这些发现表明,肠道微生物组在HSCR中发挥着重要作用.
- 针对微生物群的疗法可能是管理HSCR的潜在策略.
更多相关视频
08:33Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
Published on: November 17, 2018
13.8K
05:45Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
14.0K
相关概念视频
Anatomy of the Intestines
86.5K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.5K
Bacterial Flora of the Large Intestine
1.5K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.5K
Renewal of Intestinal Stem Cells
3.1K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.1K
Chronic Bowel Disorders: Introduction
722
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
722
