关于与hirschsprung相关的肠球炎和非hirschsprung相关的肠球炎的hirschsprung疾病的肠道微生物组概况:系统性审查
Barmadisatrio1, Z F E Hakim2, M I Akbar2
1Pediatric Surgery Division, Department of Surgery, Dr. Soetomo General-Academic Hospital, Surabaya, Indonesia. dodolily1997@gmail.com.
The Medical journal of Malaysia
|December 26, 2025
概括
肠道微生物组分析显示,蛋白质细菌与儿科患者的希尔施普朗相关肠球炎 (HAEC) 有关. 这一发现表明,微生物组失调可能是预防HAEC的关键,HAEC是赫尔施普朗格病的严重并发症.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 儿科手术 儿科手术
背景情况:
- 赫施普朗氏病 (HSCR),或角质巨肠,是一种先天性肠道疾病.
- 赫斯普朗相关肠球炎 (HAEC) 是HSCR的严重并发症,导致显著的发病率和死亡率.
- 肠道微生物组在HAEC发展和管理中的作用仍在争论中.
研究的目的:
- 在患有HSCR的儿科患者中分析肠道微生物组合.
- 为了比较具有和没有HAEC的HSCR患者之间的肠道微生物群.
- 为了确定HAEC预防的潜在微生物点.
主要方法:
- 对病例报告进行了分析描述性的系统审查.
- 从2014年1月到2024年10月,在3个数据库中进行文献搜索,遵守PRISMA指南.
- 在HSCR患者中提取和分析了肠道微生物组合及其生理影响的数据.
主要成果:
- 从最初的244个引用中,包括17篇文章在分析中.
- 蛋白质细菌被确定为患有HAEC的HSCR患者中占主导地位的细菌.
- 在没有HAEC的HSCR患者中,Bacteroidetes被发现是最常见的细菌.
结论:
- 蛋白质细菌的存在与HSCR患者的HAEC发展有关.
- 肠道微生物组失调症被认为是HAEC的一个关键因素.
- 准微生物群失调症可能是预防HAEC的策略.
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