生物标志物 生物标志物
Meng Jiang1, Nelly Joseph-Mathurin1, Yong Wang2
1Washington University School of Medicine, St. Louis, MO, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 26, 2025
概括
一般化扩散基谱成像 (g-DBSI) 显示在检测神经炎症和与粉样蛋白相关的成像异常 (ARIA-E) 相关的血管性瘤时具有前景,在AD的单克隆抗体治疗期间. 这种先进的MRI技术可能有助于监测ARIA的进展,并了解潜在的机制.
科学领域:
- 神经成像是一种神经成像.
- 先进的核磁共振成像技术.
- 神经炎症研究的神经炎症研究.
背景情况:
- 与粉样蛋白相关的成像异常 (ARIA),包括血管性胀 (ARIA-E) 和出血性病变 (ARIA-H),在阿尔茨海默病 (AD) 的单克隆抗体 (mAb) 治疗中构成挑战.
- ARIA的潜在机制,特别是神经炎症,尚不清楚.
- 先进的成像对于研究这些过程至关重要,一般化扩散基光谱成像 (g-DBSI) 显示了揭示微观结构变化的潜力.
研究的目的:
- 使用g-DBSI调查ARIA-E发育和恢复期间与神经炎症和血管性相关的微观结构变化.
- 评估g-DBSI在接受mAb治疗的患者的ARIA-E监测中的有用性.
主要方法:
- 一项试点研究涉及三名参与者接受Gantenerumab在DIAN-TU-001试验,与纵向g-DBSI扫描.
- 通过使用FDA指南和结构化报告的神经放射学小组进行ARIA评估.
- 量化g-DBSI衍生的受限比率 (RR) 作为炎症标志物和阻碍比率 (HR) 作为ARIA-E区域的血管性瘤标志物.
主要成果:
- 与随访者相比,参与者1在ARIA-E发病前一个月显示RR和HR升高.
- 参与者2在ARIA-E发病期间表现出较高的RR和HR,在两年后随访时显著下降.
- 参与者3在ARIA-E解决后的一到两年的随访期间表现出稳定的RR和HR.
结论:
- 这些发现表明神经炎症在ARIA-E进展中的作用.
- g-DBSI显示了在ARIA-E发作之前检测微观结构变化的潜力.
- g-DBSI可以作为监测ARIA进展和理解神经炎症和的非侵入性工具,这需要在更大的队列中进行进一步的研究.
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